Viral Rebound and Emergence of Drug Resistance in the Absence of Viral Load Testing: A Randomized Comparison between Zidovudine-Lamivudine plus Nevirapine and Zidovudine-Lamivudine plus Abacavir

BackgroundWe investigated virological response and the emergence of resistance in the Nevirapine or Abacavir (NORA) substudy of the Development of Antiretroviral Treatment in Africa (DART) trial MethodsSix hundred symptomatic antiretroviral-naive human immunodeficiency virus (HIV)-infected adults (C...

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Bibliographic Details
Published in:The Journal of infectious diseases 2010-01, Vol.201 (1), p.106-113
Main Authors: Ndembi, Nicasie, Goodall, Ruth L., Dunn, David T., McCormick, Adele, Burke, Andy, Lyagoba, Fred, Munderi, Paula, Katundu, Pauline, Kityo, Cissy, Robertson, Val, Yirrell, David L., Walker, A. Sarah, Gibb, Diane M., Gilks, Charles F., Kaleebu, Pontiano, Pillay, Deenan
Format: Article
Language:English
Subjects:
Adult
AIDS
Anti-Retroviral Agents - therapeutic use
Antiretrovirals
Biological and medical sciences
CD4 Lymphocyte Count
Clinical trials
Dideoxynucleosides - therapeutic use
Drug Resistance, Viral - genetics
Drug Therapy, Combination
Female
Fundamental and applied biological sciences. Psychology
Genetic mutation
HIV
HIV 1
HIV Infections - drug therapy
HIV Infections - virology
HIV/AIDS
Human immunodeficiency virus
Human immunodeficiency virus 2
Humans
Infectious diseases
Kaplan-Meier Estimate
Lamivudine - therapeutic use
Male
Medical sciences
Microbiology
Mutation
Nevirapine - therapeutic use
Nucleosides
RNA
RNA, Viral
Uganda
Viral Load
Virology
Zidovudine - therapeutic use
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Summary:BackgroundWe investigated virological response and the emergence of resistance in the Nevirapine or Abacavir (NORA) substudy of the Development of Antiretroviral Treatment in Africa (DART) trial MethodsSix hundred symptomatic antiretroviral-naive human immunodeficiency virus (HIV)-infected adults (CD4 cell count, 1000 copies/mL, the residual activity of therapy was calculated as the reduction in HIV RNA level, compared with baseline ResultsOverall, HIV RNA levels were lower in the nevirapine group than in the abacavir group at 24 and 48 weeks (P
ISSN:0022-1899
1537-6613
DOI:10.1086/648590