Chloroperoxidase-catalysed oxidation of alcohols to aldehydes

Chloroperoxidase (CPO) catalyses the oxidation of primary alcohols (hexan-1-ol, hexen-1-ols, epoxyhexan-1-ols and 3-phenylglycidol) selectively to the aldehyde in biphasic systems of hexane or ethyl acetate and a buffer (pH 5.0). The cis to trans isomerization in the case of cis-2-hexenal can be avo...

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Bibliographic Details
Published in:Journal of molecular catalysis. B, Enzymatic Enzymatic, 2000-04, Vol.9 (4), p.163-172
Main Authors: Kiljunen, Eero, Kanerva, Liisa T
Format: Article
Language:English
Subjects:
Alcohol oxidation
Aldehydes
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Catalysis
Chlorine compounds
Chloroperoxidase
Enzymes
Fundamental and applied biological sciences. Psychology
Hydrogen peroxide
Isomerization
Methods. Procedures. Technologies
Organic solvents
Oxidation
Saturation (materials composition)
Two-phase system
Water
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Summary:Chloroperoxidase (CPO) catalyses the oxidation of primary alcohols (hexan-1-ol, hexen-1-ols, epoxyhexan-1-ols and 3-phenylglycidol) selectively to the aldehyde in biphasic systems of hexane or ethyl acetate and a buffer (pH 5.0). The cis to trans isomerization in the case of cis-2-hexenal can be avoided by working at low water contents or in organic solvents saturated with water. In the case of epoxyalcohols, oxidation to the aldehyde proceeds enantioselectively. Hydrogen peroxide and tert-butyl hydroperoxide have been used as an oxidant.
ISSN:1381-1177
1873-3158
DOI:10.1016/S1381-1177(99)00093-4