Comparison of local deposition densities of inhaled aerosols in human and rat airways

The local deposition density maxima in characteristic regions of the human and rat lungs were computed to quantify the differences in the corresponding aerosol deposition patterns applying the numerical deposition models of I. Balashazy and W. Hoffman (1993; 1995), and I. Balashazy (1994). Depositio...

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Bibliographic Details
Published in:Journal of aerosol science 1999-09, Vol.30 (Suppl. 1), p.S727-S728
Main Authors: Nagy, A., Lo˝rinc, M., Láng, E., Vértes, P., Hegedu˝s, Cs, Szabó, P.P.
Format: Article
Language:English
Subjects:
Bifurcation (mathematics)
Biology
Density (specific gravity)
Monte Carlo methods
Particles (particulate matter)
Pulmonary diseases
Respiratory mechanics
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Summary:The local deposition density maxima in characteristic regions of the human and rat lungs were computed to quantify the differences in the corresponding aerosol deposition patterns applying the numerical deposition models of I. Balashazy and W. Hoffman (1993; 1995), and I. Balashazy (1994). Deposition patterns are simulated in three-dimensional model bifurcations for two typical geometries segmental bronchi (generations 4-5) and terminal bronchioles (generations 15-16) for inspiration and expiration. The linear dimensions of these branchings are computed via the stochastic lung motel of L. Koblinger and W. Hoffman (1990). The observed interspecies differences in localized particle deposition patterns and in related enhancement factors reveal that the respective morphometric asymmetries in airway branching are a major determinant of the local distributions of deposited particulate matter in bronchial airway bifurcations.
ISSN:0021-8502
1879-1964
DOI:10.1016/S0021-8502(99)80374-7