Occupational Exposures and Breast Cancer among Women Textile Workers in Shanghai

Background: Breast cancer incidence rates have been increasing in China over the past 2 decades. Most studies have focused on reproductive, dietary, and genetic risk factors. Little is known about the contribution of occupational exposures. Methods: We conducted a case-cohort study within a cohort o...

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Bibliographic Details
Published in:Epidemiology (Cambridge, Mass.) Mass.), 2007-05, Vol.18 (3), p.383-392
Main Authors: Ray, Roberta M., Gao, Dao Li, Li, Wenjin, Wernli, Karen J., Astrakianakis, George, Seixas, Noah S., Camp, Janice E., Fitzgibbons, E. Dawn, Feng, Ziding, Thomas, David B., Checkoway, Harvey
Format: Article
Language:English
Subjects:
Age Factors
Air Pollutants, Occupational - adverse effects
Biological and medical sciences
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - etiology
Chemical hazards
China - epidemiology
Cohort Studies
Cotton
Dust - analysis
Endotoxins
Endotoxins - analysis
Epidemiology
Female
Gynecology. Andrology. Obstetrics
Humans
Inhalation Exposure - adverse effects
Live births
Mammary gland diseases
Medical sciences
Middle Aged
Miscellaneous
Occupational Diseases - epidemiology
Occupational Exposure - adverse effects
Occupational medicine
Predisposing factors
Proportional Hazards Models
Public health. Hygiene
Public health. Hygiene-occupational medicine
Textile industry
Textiles
Time Factors
Tumors
Vivipary
Working women
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Summary:Background: Breast cancer incidence rates have been increasing in China over the past 2 decades. Most studies have focused on reproductive, dietary, and genetic risk factors. Little is known about the contribution of occupational exposures. Methods: We conducted a case-cohort study within a cohort of female textile workers who had participated in a randomized trial of breast self-examination in Shanghai, China. We compared 1709 incident breast cancer cases with an age-stratified reference subcohort (n = 3155 noncases). Cox proportional hazards modeling, adapted for the case-cohort design, was used to estimate hazard ratios for breast cancer in relation to duration of employment in various job processes and duration of exposure to several agents. We also evaluated the associations of cotton dust and endotoxin with breast cancer. Results: Cumulative exposures to cotton dust and endotoxin demonstrated strong inverse gradients with breast cancer risk when exposures were lagged by 20 years (trend P-values
ISSN:1044-3983
1531-5487
DOI:10.1097/01.ede.0000259984.40934.ae