Occupational Exposures and Ovarian Cancer in Textile Workers

Background: Occupational risk factors for ovarian cancer have been investigated only to a limited extent. We conducted a case-cohort study to examine associations between occupational exposures and ovarian cancer in the textile industry. Methods: We compared 261 incident ovarian cancer cases diagnos...

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Bibliographic Details
Published in:Epidemiology (Cambridge, Mass.) Mass.), 2008-03, Vol.19 (2), p.244-250
Main Authors: Wernli, Karen J., Ray, Roberta M., Gao, Dao Li, Fitzgibbons, E. Dawn, Camp, Janice E., Astrakianakis, George, Seixas, Noah, Wong, Eva Y., Li, Wenjin, De Roos, Anneclaire J., Feng, Ziding, Thomas, David B., Checkoway, Harvey
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cancer
Case-Control Studies
China - epidemiology
Cohort Studies
Cotton
Cotton Fiber
Dust - analysis
Endotoxins
Endotoxins - toxicity
Epidemiology
Female
Female genital diseases
Gram-Negative Bacteria
Gynecology. Andrology. Obstetrics
Humans
Manufacturing processes
Medical sciences
Middle Aged
Miscellaneous
Occupational Exposure - adverse effects
Occupational Exposure - analysis
Occupational medicine
Ovarian cancer
Ovarian Neoplasms - epidemiology
Ovarian Neoplasms - etiology
Ovarian Neoplasms - prevention & control
Predisposing factors
Proportional Hazards Models
Public health. Hygiene
Public health. Hygiene-occupational medicine
Randomized Controlled Trials as Topic
Risk Factors
Silicon Dioxide - toxicity
Solvents
Textile Industry
Textile processes
Time Factors
Tumors
Working women
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Summary:Background: Occupational risk factors for ovarian cancer have been investigated only to a limited extent. We conducted a case-cohort study to examine associations between occupational exposures and ovarian cancer in the textile industry. Methods: We compared 261 incident ovarian cancer cases diagnosed between 1989 and 1998 with an age-stratified reference subcohort (n = 3199) from a cohort of 267,400 textile workers in Shanghai, China. Occupational exposures were assessed by job-exposure matrices designed for the textile industry, and estimates of quantitative cotton dust and endotoxin. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) with Cox proportional hazards modeling adapted for the case-cohort design. Results: A decreased risk of ovarian cancer was associated with ever having worked in cotton manufacturing production (HR = 0.7; 95% CI = 0.4-1.0). An increased risk was associated with ever having worked in textile finishing (2.1; 0.9-5.0). We found an increasing risk of ovarian cancer associated with cumulative exposure to silica dust (for
ISSN:1044-3983
1531-5487
DOI:10.1097/EDE.0b013e31816339f9