Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent

We prepared PEGylated magnetoliposomes (ML-PEG) with a diameter of 40 nm and containing 1–6 superparamagnetic iron oxide crystals per vesicle. The T1 and T2 relaxivities were 3 and 240 s −1/mM at 1.5 T and 37°C. In rats, ML-PEG showed a biexponential clearance with a long blood half-life of 53.2±13....

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 1999, Vol.194 (1), p.204-209
Main Authors: Bulte, Jeff W.M., Cuyper, Marcel de, Despres, Daryl, Frank, Joseph A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells
Contrast agent
Contrast media. Radiopharmaceuticals
Drug therapy
Investigative techniques, diagnostic techniques (general aspects)
Iron oxides
Liposome
Magnetic relaxation
Magnetic resonance imaging
Medical sciences
Miscellaneous. Technology
MR imaging
Paramagnetism
Pharmacology. Drug treatments
Polyethylene glycols
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Superparamagnetic iron oxide
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Summary:We prepared PEGylated magnetoliposomes (ML-PEG) with a diameter of 40 nm and containing 1–6 superparamagnetic iron oxide crystals per vesicle. The T1 and T2 relaxivities were 3 and 240 s −1/mM at 1.5 T and 37°C. In rats, ML-PEG showed a biexponential clearance with a long blood half-life of 53.2±13.2 min. Using MR imaging, ML-PEG was found to have excellent properties as a bone marrow-seeking MR contrast agent.
ISSN:0304-8853
DOI:10.1016/S0304-8853(98)00556-3