Association of Maternal Prepregnancy Weight with Offspring Adiposity Throughout Adulthood over 37 Years of Follow‐up

Objective This study aimed to determine the relation of maternal prepregnancy weight with offspring BMI across adulthood from almost 40 years of follow‐up. Methods BMI was measured in Framingham Heart Study Offspring cohort participants between 1971 and 2008. The association of maternal prepregnancy...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2019-01, Vol.27 (1), p.137-144
Main Authors: Schoppa, Isabelle, Lyass, Asya, Heard‐Costa, Nancy, de Ferranti, Sarah D., Fox, Caroline, Gillman, Matthew W., D’Agostino, Ralph, Levy, Daniel, Mendelson, Michael M.
Format: Article
Language:English
Subjects:
Adiposity - genetics
Adult
Adults
Age
Cardiovascular disease
Cohort Studies
Diabetes
DNA methylation
Epigenetics
Female
Follow-Up Studies
Gestational Weight Gain - physiology
Health risk assessment
Humans
Hypotheses
Longitudinal Studies
Male
Obesity
Obesity - etiology
Obesity - pathology
Pregnancy
Questionnaires
Risk Factors
Studies
Weight control
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Summary:Objective This study aimed to determine the relation of maternal prepregnancy weight with offspring BMI across adulthood from almost 40 years of follow‐up. Methods BMI was measured in Framingham Heart Study Offspring cohort participants between 1971 and 2008. The association of maternal prepregnancy weight category (ascertained via direct measure and questionnaire) with serial offspring BMI, overweight, obesity, and change in BMI over time was tested, adjusted for age, sex, and a BMI genetic risk score; secondary models additionally adjusted for physical activity, dietary factors, smoking, education, and familial relatedness. Results Among 863 participants at initial assessment (83 exposed and 780 controls), mean (SD) age was 33 (10) years, 53% were female, and mean BMI was 24.5 (4.1) kg/m2. Exposed offspring BMI was higher at every examination cycle, ranging from 1.5 (0.5) to 3.0 (0.5) kg/m2 (P 
ISSN:1930-7381
1930-739X
1930-739X
DOI:10.1002/oby.22326