Predictors of hospital discharge in cancer patients with pericardial effusion undergoing surgical pericardial drainage

Introduction Pericardial effusion (PE) is a complication of late‐stage cancer and some patients never leave the hospital despite drainage. The main objective of this study was to identify predictors of hospital discharge in cancer patients with (PE) who underwent pericardial drainage. We also report...

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Published in:Journal of surgical oncology 2019-01, Vol.119 (1), p.143-147
Main Authors: Kazantzis, Thamara, Bibas, Benoit Jacques, Dela‐Vega, Alberto Jorge, Nabuco, Pedro, Lauricella, Leticia Leone, Pêgo‐Fernandes, Paulo Manuel, Terra, Ricardo Mingarini
Format: Article
Language:English
Subjects:
Cancer surgery
Chemotherapy
Discharge
hospital discharge
malignant pericardial effusion
paradoxical hemodynamic instability (PHI)
pericardial drainage
pericardial effusion (PE)
Side effects
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Summary:Introduction Pericardial effusion (PE) is a complication of late‐stage cancer and some patients never leave the hospital despite drainage. The main objective of this study was to identify predictors of hospital discharge in cancer patients with (PE) who underwent pericardial drainage. We also report the occurrence of paradoxical hemodynamic instability (PHI). Methods and Materials A retrospective study was carried out in a cancer center. Patients included had malignancy, PE, and underwent surgical drainage. An institutional database was reviewed for preoperative variables, analyzed for hospital discharge. Results One‐hundred and thirteen patients were included, with a mean age of 54 years old (SD 14.3). Sixty‐three patients were discharged from hospital (55.7%). Age (odds ratio [OR], 1.04; P = 0.004), higher ECOG status (OR, 0.63; P = 0.019), recent chemotherapy (OR, 3.40; P = 0.007), and renal failure (OR, 0.14; P = 0.002) were associated with hospital discharge. Median survival was 43 days (IQ 25%‐75%; 15‐162). Patients with pulmonary embolism or neutropenia were at greater risk of developing PHI (OR, 10.11; P = 0.009 and OR, 12.13; P = 0.015, respectively). Conclusion Almost half of the patients never left the hospital. Patients with no chemotherapy within 45 days of procedure, patients with renal failure and higher ECOG status are at greater risk of not getting discharged. PHI remains a serious condition with high mortality.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.25283