Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans

Increased body fat may be associated with an increased risk of developing an underlying pro-inflammatory state, thus leading to greater risk of developing certain chronic conditions. Immunoglobulin G has the ability to exert both anti- and pro-inflammatory effects, and the N-glycosylation of the fra...

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Bibliographic Details
Published in:Immunobiology (1979) 2019-01, Vol.224 (1), p.110-115
Main Authors: Russell, Alyce C., Kepka, Agnieszka, Trbojević-Akmačić, Irena, Ugrina, Ivo, Song, Manshu, Hui, Jennie, Hunter, Michael, Laws, Simon M., Lauc, Gordan, Wang, Wei
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adipose Tissue - diagnostic imaging
Adiposity - physiology
Aged
Anthropometry
Australia - epidemiology
Body Mass Index
Central adiposity
Chromatography, Liquid
Community-Based Participatory Research
Female
Glycosylation
Humans
Immunoglobulin G
Immunoglobulin G - chemistry
Immunoglobulin G - metabolism
Inflammation Mediators - chemistry
Inflammation Mediators - metabolism
Male
Middle Aged
Obesity - epidemiology
Pro-inflammation
Risk Factors
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Summary:Increased body fat may be associated with an increased risk of developing an underlying pro-inflammatory state, thus leading to greater risk of developing certain chronic conditions. Immunoglobulin G has the ability to exert both anti- and pro-inflammatory effects, and the N-glycosylation of the fragment crystallisable portion is involved in mediating this process. Body mass index, a rudimentary yet gold standard indication for body fat, has been shown to be associated with agalactosylated immunoglobulin G N-glycans. We aimed to determine the association between increased body fat and the immunoglobulin G glycosylation features, comparing body mass index to other measures of body fat distribution. We investigated a sample of 637 community-based 45–69 year olds, with mixed phenotypes, residing in Busselton, Western Australia. Body mass index and the waist-to-hip and waist-to-height ratios were calculated using anthropometry, while dual-energy x-ray absorptiometry was performed to gain an accurate measure of total and area specific body fat. Serum immunoglobulin GN-glycans were analysed by ultra-performance liquid chromatography. Twenty-two N-glycan peaks were found to be associated with at least one of the fat measures. While the previous association of body mass index to agalactosylated immunoglobulin G was replicated, measures of central adiposity explained the most variation in the immunoglobulin G glycome. Central adiposity is associated with an increased pro-inflammatory fraction of immunoglobulin G, suggesting that the android/gynoid ratio or waist-to-height ratio instead be considered when controlling for adiposity in immunoglobulin G glycome biomarker studies.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2018.10.002