Biocompatibility studies of anionic collagen membranes with different degree of glutaraldehyde cross-linking

The work describes the biocompatibility and biodegradation studies of anionic collagen membranes casted form collagen gels collagen, that were selective hydrolyzed at the carboxyamide groups, as a function of the degree of cross-links induced by glutaraldehyde. Independently from the degree of cross...

Full description

Saved in:
Bibliographic Details
Published in:Biomaterials 1999, Vol.20 (1), p.27-34
Main Authors: Goissis, Gilberto, Marcantonio, Elcio, Marcantônio, Rosemary Adriana Chierici, Lia, Rafael Carlos Comelli, Cancian, Daniela C.J., Carvalho, Wanda Maria de
Format: Article
Language:English
Subjects:
Animals
Anionic collagen
Biocompatibility
Biocompatible Materials
Biodegradation
Biodegradation, Environmental
Biological and medical sciences
Biological membranes
Biomaterials
Cattle
Collagen - chemistry
Collagen - pharmacokinetics
Cross-Linking Reagents
Cross-links
Crosslinking
Dentistry
Drug Stability
Gels
Glutaral
Glutaraldehyde
Hot Temperature
Male
Medical sciences
Membranes, Artificial
Prostheses and Implants
Rats
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Tendons
Thermodynamics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The work describes the biocompatibility and biodegradation studies of anionic collagen membranes casted form collagen gels collagen, that were selective hydrolyzed at the carboxyamide groups, as a function of the degree of cross-links induced by glutaraldehyde. Independently from the degree of cross-links, all membranes studied were characterized by a similar inflammatory response, inversely dependent on glutaraldehyde reaction time, that decreased from the time of the implant. Cell alterations, mineralization or contact necrosis were not observed in any of the membranes studied. Rates for membrane tissue biodegradation were directly related to glutaraldehyde reaction time, and ranged from 30 to periods longer than 60 days, associated with good biocompatibility. Although other properties must be considered, their use in the treatment of periodontal diseases, the biological behavior observed with the 8 h GA cross-linked membrane suggests that, anionic collagen membrane described in this work may be of potential use, not only in association with guided tissue regeneration technique for periodontal tissue reconstruction, but also in other collagen biomaterial applications where controlled biodegradability is required.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(97)00198-1