Sex‐specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

Summary Objective Studies of dehydroepiandrosterone (DHEA) therapy in older adults suggest sex‐specific effects on bone mineral density (BMD) and body composition, but the ability of a single study to reach this conclusion was limited. We evaluated the effects of DHEA on sex hormones, BMD, fat mass...

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Published in:Clinical endocrinology (Oxford) 2019-02, Vol.90 (2), p.293-300
Main Authors: Jankowski, Catherine M., Wolfe, Pamela, Schmiege, Sarah J., Nair, K. Sreekumaran, Khosla, Sundeep, Jensen, Michael, von Muhlen, Denise, Laughlin, Gail A., Kritz‐Silverstein, Donna, Bergstrom, Jaclyn, Bettencourt, Richele, Weiss, Edward P., Villareal, Dennis T., Kohrt, Wendy M.
Format: Article
Language:English
Subjects:
17β-Estradiol
Aged
ageing
Body composition
Body Composition - drug effects
Body fat
Bone composition
Bone density
Bone Density - drug effects
Bone mass
Bone mineral density
Clinical trials
Data processing
Dehydroepiandrosterone
Dehydroepiandrosterone - metabolism
Dehydroepiandrosterone - pharmacology
Estrogens
fat mass
fat‐free mass
Female
Femur - drug effects
Hip
Hormone Replacement Therapy
Humans
Insulin
Insulin-like growth factors
Lumbar Vertebrae - drug effects
Male
Middle Aged
Pelvic Bones - drug effects
prohormone
Randomized Controlled Trials as Topic
sex differences
Sex Factors
Sex hormones
Spine (lumbar)
Testosterone
Trochanter
Women
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Summary:Summary Objective Studies of dehydroepiandrosterone (DHEA) therapy in older adults suggest sex‐specific effects on bone mineral density (BMD) and body composition, but the ability of a single study to reach this conclusion was limited. We evaluated the effects of DHEA on sex hormones, BMD, fat mass and fat‐free mass in older women and men enrolled in four similar clinical trials. Design Pooled analyses of data from four double‐blinded, randomized controlled trials. Participants Women (n = 295) and men (n = 290) aged 55 years or older who took DHEA or placebo tablet daily for 12 months. Measurements Twelve‐month changes in BMD, fat mass, fat‐free mass and serum DHEA sulphate (DHEAS), (17)estradiol, testosterone and insulin‐like growth factor‐1 (IGF‐1). Results Women on DHEA had increases (mean ± SD; all P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.13901