Dynamics of nonstructural glycoprotein‐1 in dengue patients presenting with different clinical manifestations from 1986 to 2012 in Rio de Janeiro, Brazil

The hyperendemicity and co‐circulation of different dengue serotypes in Brazil have increased the number of severe dengue cases and the rate of hospitalization for dengue. Virological and individual factors are associated with the complexity of the disease. Antigenemia levels of nonstructural glycop...

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Bibliographic Details
Published in:Journal of medical virology 2019-04, Vol.91 (4), p.555-563
Main Authors: Gonçalves, Bianca De Santis, Horta, Marco Aurélio Pereira, Acero, Pedro Hernan Cabello, Bochner, Rosany, Queiroz Lima, Monique da Rocha, Araújo, Eliane Saraiva, Sampaio, Simone Alves, Nogueira, Rita Maria Ribeiro, Filippis, Ana Maria Bispo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral - blood
Antigen presentation
Antigenemia
biomarker
Brazil
Dengue - pathology
Dengue - virology
Dengue fever
Dengue hemorrhagic fever
Dengue Virus - genetics
Dengue Virus - immunology
Dengue Virus - isolation & purification
Enzyme-Linked Immunosorbent Assay
Female
Glycoproteins
Glycoproteins - genetics
Hospitalization
Humans
Immune response
Immune system
Male
Middle Aged
nonstructural glycoprotein‐1
Patients
Real-Time Polymerase Chain Reaction
Retrospective Studies
Ribonucleic acid
RNA
RNA, Viral - blood
RNA, Viral - genetics
Serogroup
Serotypes
severe dengue
Vector-borne diseases
Viral diseases
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - immunology
Viremia
Virology
Warning
warning signs
Young Adult
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Summary:The hyperendemicity and co‐circulation of different dengue serotypes in Brazil have increased the number of severe dengue cases and the rate of hospitalization for dengue. Virological and individual factors are associated with the complexity of the disease. Antigenemia levels of nonstructural glycoprotein‐1 (NS1) have been associated with severe dengue. Aiming to identify a severity marker during the acute phase (days 0 to 5 of disease), the association of NS1 antigenemia with clinical presentation, sex, age range, immune response, number of days of disease, and serotype RNA levels was evaluated in serum samples of patients from the state of Rio de Janeiro clinically classified as having dengue without warning signs (DWWS) or dengue with warning signs/severe dengue (DWWS/SD). The immune response was classified by in‐house enzyme‐linked immunosorbent assay, antigenemia was determined by quantification of NS1, and viremia was quantified by real‐time PCR. Of the total number of patients, 36.6% (74 of 202) presented warning signs/severe dengue and 72.3% (146 of 202) were classified with primary infection. DENV‐2 presented an association between clinical presentation and antigenemia (P = 0.02). DENV‐3 had higher levels of NS1 (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.25356