A stereoselective sequential organocascade and multicomponent approach for the preparation of tetrahydropyridines and chimeric derivatives

A stereoselective multicomponent approach leading to a novel class of pentasubstituted tetrahydropyridines is described. Variation of the components enabled the incorporation of peptide, sugar and steroid moieties to access chimeric derivatives. DFT calculations provide insights about the unpreceden...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-01, Vol.55 (3), p.286-289
Main Authors: Echemendía, Radell, da Silva, Gustavo P, Kawamura, Meire Y, de la Torre, Alexander F, Corrêa, Arlene G, Ferreira, Marco A B, Rivera, Daniel G, Paixão, Márcio W
Format: Article
Language:English
Subjects:
Derivatives
Mathematical analysis
NMR
Nuclear magnetic resonance
Stereoselectivity
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Summary:A stereoselective multicomponent approach leading to a novel class of pentasubstituted tetrahydropyridines is described. Variation of the components enabled the incorporation of peptide, sugar and steroid moieties to access chimeric derivatives. DFT calculations provide insights about the unprecedented high diastereoselectivity of the MCR.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc06871b