Egg OIT in clinical practice (SEICAP II): Maintenance patterns and desensitization state after normalizing the diet

Background It is unknown which are the most suitable maintenance pattern and egg consumption to maintain the desensitization state after ending the oral immunotherapy (OIT). This multicenter, randomized, controlled trial compared two OIT maintenance patterns with pasteurized egg white (PEW), evaluat...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric allergy and immunology 2019-03, Vol.30 (2), p.214-224
Main Authors: Martín‐Muñoz, María Flora, Alonso Lebrero, Elena, Zapatero, Lidia, Fuentes Aparicio, Victoria, Piquer Gibert, Mónica, Plaza Martín, Ana María, Muñoz, Candelaria, Belver, María Teresa, Martorell‐Calatayud, Cristina, Martorell‐Aragonés, Antonio, Blasco, Cristina, Vilá, Blanca, Gómez, Catalina, Nevot, Santiago, García Martín, Juan Miguel, Madero, Rosario, Echeverría, Luis, Eigenmann, Philippe
Format: Article
Language:English
Subjects:
Administration, Oral
Albumen
Allergens - administration & dosage
Allergens - immunology
Allergies
Biomarkers - blood
Child
Child, Preschool
Children
Desensitization
Desensitization (Psychology)
desensitization state
Desensitization, Immunologic - adverse effects
Desensitization, Immunologic - methods
Diet
Diet - adverse effects
Diet - methods
effects of the egg consumption after ending the OIT
egg allergy
egg consumption after OIT and desensitization state
Egg Hypersensitivity - therapy
egg OIT
Egg White
evolution of adverse reactions through OIT and 12 months after ending OIT
Humans
Immunoglobulin E
Immunotherapy
Infant
OIT maintenance patterns
Pasteurization
Patient Compliance - statistics & numerical data
Proteins
Randomization
Serum levels
Side effects
Skin tests
Skin Tests - methods
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background It is unknown which are the most suitable maintenance pattern and egg consumption to maintain the desensitization state after ending the oral immunotherapy (OIT). This multicenter, randomized, controlled trial compared two OIT maintenance patterns with pasteurized egg white (PEW), evaluating the egg consumption effect on the desensitization state after ending the OIT. Methods One hundred and one children with confirmed egg allergy were randomized: 25 to an egg‐free diet (CG) and 76 to an OIT year with PEW and two maintenance patterns, 38 patients to daily 3.3 g proteins (AG) and 38 to every two days (BG). PEW challenge (DBPCFC), adverse reactions, and immune markers were assessed at baseline, at the end of the OIT, and at 6 and 12 months later on ad libitum egg consumption (T0, T12, T18, and T24). A questionnaire evaluated the egg consumption at T18. Results At T12, 64 of 76 (84.21%) OIT patients had reached total desensitization (32 AG and 32 BG) vs 4 of 25 (16.00%) CG who passed the PEW DBPCFC. Thirty (93.75%) AG vs 25 (78.12%) BG patients completed an OIT year. At T18, 27 of 29 (93.1%) AG vs 20 of 24 (83.3%) BG passed the PEW DBPCFC, 96% consuming at least two egg servings/week. At T24, 97.43% OIT patients passed the challenge. Most patients had adverse reactions, more frequent in the BG patients; frequency and severity of reactions decreased through the study. PEW skin prick test wheal and sIgE antibody serum levels similarly decreased in AG or BG, but AG patients had greater increase in PEW sIgG4 (P 
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.13002