Hypopharyngeal cancer: A state of the art review

•Hypopharyngeal squamous cell carcinoma has a reported 5-year overall survival rate of approximately 30–35%.•Nearly 50% of patients exhibitrecurrence within the first year after diagnosis.•Laryngeal preservation strategies are well supported although long term toxicity is significant.•Salvage surger...

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Bibliographic Details
Published in:Oral oncology 2018-11, Vol.86, p.244-250
Main Authors: Garneau, Jonathan C., Bakst, Richard L., Miles, Brett A.
Format: Article
Language:English
Subjects:
Clinical Trials as Topic
Disease-Free Survival
Head and neck squamous cell carcinoma
Humans
Hypopharyngeal cancer
Hypopharyngeal carcinoma
Hypopharyngeal Neoplasms - mortality
Hypopharyngeal Neoplasms - therapy
Hypopharynx - pathology
Hypopharynx - radiation effects
Hypopharynx - surgery
Laryngeal preservation
Larynx - radiation effects
Neoplasm Recurrence, Local - epidemiology
Neoplasm Recurrence, Local - prevention & control
Organ Sparing Treatments - adverse effects
Organ Sparing Treatments - methods
Organs at Risk - radiation effects
Prognosis
Radiotherapy, Adjuvant - adverse effects
Radiotherapy, Adjuvant - methods
Review Literature as Topic
Salvage Therapy - adverse effects
Salvage Therapy - methods
Squamous Cell Carcinoma of Head and Neck - mortality
Squamous Cell Carcinoma of Head and Neck - therapy
Survival Rate
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Summary:•Hypopharyngeal squamous cell carcinoma has a reported 5-year overall survival rate of approximately 30–35%.•Nearly 50% of patients exhibitrecurrence within the first year after diagnosis.•Laryngeal preservation strategies are well supported although long term toxicity is significant.•Salvage surgery a common occurrence.•Future directions will focus on immunotherapy/targeted therapies to improve survival outcomes. Cancer of the hypopharynx is relatively rare and accounts for roughly 3% of all head and neck cancers. Unfortunately, hypopharyngeal carcinoma has one of the worst prognosis of all head and neck cancers with a reported 5-year overall survival rate of approximately 30–35%. Toxicity related to therapy, and the need for surgical salvage continue to dominate the landscape in this disease. In this article, we set out to discuss a comprehensive overview of the current management principles, recent literature and evidence based therapeutic options surrounding treatment for hypopharyngeal squamous cell carcinoma, with a special focus on the evolution of an organ sparing paradigm.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2018.09.025