Loading…
Short-term Pasteurization of Breast Milk to Prevent Postnatal Cytomegalovirus Transmission in Very Preterm Infants
Postnatally acquired cytomegalovirus (pCMV) infection through breast milk (BM) may cause severe illness and even death, yet BM is advantageous for preterm infants. Therefore, effective methods to prevent CMV transmission are needed. To assess the effectiveness of short-term pasteurization (62°C for...
Saved in:
Published in: | Clinical infectious diseases 2019-07, Vol.69 (3), p.438-444 |
---|---|
Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c353t-d14171a4f3fd341877c17afa1878474162730bcda0677b724b387ff9d74c8f3a3 |
---|---|
cites | cdi_FETCH-LOGICAL-c353t-d14171a4f3fd341877c17afa1878474162730bcda0677b724b387ff9d74c8f3a3 |
container_end_page | 444 |
container_issue | 3 |
container_start_page | 438 |
container_title | Clinical infectious diseases |
container_volume | 69 |
creator | Bapistella, Sascha Hamprecht, Klaus Thomas, Wolfgang Speer, Christian P Dietz, Klaus Maschmann, Jens Poets, Christian F Goelz, Rangmar |
description | Postnatally acquired cytomegalovirus (pCMV) infection through breast milk (BM) may cause severe illness and even death, yet BM is advantageous for preterm infants. Therefore, effective methods to prevent CMV transmission are needed.
To assess the effectiveness of short-term pasteurization (62°C for 5 seconds) in preventing CMV transmission via BM in preterm infants. Design: Prospective interventional bicentric cohort study with infant enrollment between 6/2010 and 1/2012. A cohort from the Tuebingen neonatal intensive care unit (NICU) from 1995-1998 served as historical controls. Differences in CMV transmission were compared with reference to the cumulative time at risk for CMV transmission. Setting: Two German level-3 NICUs. Eighty-seven preterm infants of 69 CMV immunoglobulin G-positive mothers with birth weight |
doi_str_mv | 10.1093/cid/ciy945 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2131237608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2131237608</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-d14171a4f3fd341877c17afa1878474162730bcda0677b724b387ff9d74c8f3a3</originalsourceid><addsrcrecordid>eNo9kF1LwzAUhoMobk5v_AGSSxGqSZM26aUOPwYTB05vS9omGm2TmaSD-uvN3PTicA6H57wcHgBOMbrEqCBXtW5iDQXN9sAYZ4QleVbg_TijjCeUEz4CR95_IIQxR9khGBFEEctwOgbu-d26kATpOrgQPsje6W8RtDXQKnjjZNzBR91-wmDhwsm1NAEurA9GBNHC6RBsJ99Ea9fa9R4unTC-095vArSBr9INm7Pf_JlRwgR_DA6UaL082fUJeLm7XU4fkvnT_Wx6PU9qkpGQNJhihgVVRDWEYs5YjZlQIk6cMorzlBFU1Y1AOWMVS2lFOFOqaBituSKCTMD5Nnfl7FcvfSjjY7VsW2Gk7X2ZYoJTwnLEI3qxRWtnvXdSlSunO-GGEqNy47iMjsut4wif7XL7qpPNP_onlfwABQV57A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2131237608</pqid></control><display><type>article</type><title>Short-term Pasteurization of Breast Milk to Prevent Postnatal Cytomegalovirus Transmission in Very Preterm Infants</title><source>Oxford Academic</source><creator>Bapistella, Sascha ; Hamprecht, Klaus ; Thomas, Wolfgang ; Speer, Christian P ; Dietz, Klaus ; Maschmann, Jens ; Poets, Christian F ; Goelz, Rangmar</creator><creatorcontrib>Bapistella, Sascha ; Hamprecht, Klaus ; Thomas, Wolfgang ; Speer, Christian P ; Dietz, Klaus ; Maschmann, Jens ; Poets, Christian F ; Goelz, Rangmar</creatorcontrib><description>Postnatally acquired cytomegalovirus (pCMV) infection through breast milk (BM) may cause severe illness and even death, yet BM is advantageous for preterm infants. Therefore, effective methods to prevent CMV transmission are needed.
To assess the effectiveness of short-term pasteurization (62°C for 5 seconds) in preventing CMV transmission via BM in preterm infants. Design: Prospective interventional bicentric cohort study with infant enrollment between 6/2010 and 1/2012. A cohort from the Tuebingen neonatal intensive care unit (NICU) from 1995-1998 served as historical controls. Differences in CMV transmission were compared with reference to the cumulative time at risk for CMV transmission. Setting: Two German level-3 NICUs. Eighty-seven preterm infants of 69 CMV immunoglobulin G-positive mothers with birth weight <1500 g or gestational age <32 weeks and 83 historical controls were included. Intervention: BM samples were short-term pasteurized from postnatal day 4 to discharge. Primary endpoint: CMV status at discharge, evaluated by polymerase chain reaction and short-term microculture from urine.
Two of 87 (2.3%) study infants had a pCMV transmission. This compared to 17 of 83 (20.5%) controls. Total time under risk for infection was 9.6 years vs 10.0 years in controls, yielding an incidence of 0.21/year (95% confidence interval [CI], 0.03 to 0.75/year) vs 1.70/year (95% CI, 0.99 to 2.72/year), respectively. The risk ratio controls vs study infants was 8.3 (95% CI, 2.4 to 52.4) according to Cox proportional hazard model (P = .0003).
Short-term pasteurization significantly reduces the incidence of pCMV infection through BM in the NICU.
NCT01178905.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciy945</identifier><identifier>PMID: 30407512</identifier><language>eng</language><publisher>United States</publisher><ispartof>Clinical infectious diseases, 2019-07, Vol.69 (3), p.438-444</ispartof><rights>The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-d14171a4f3fd341877c17afa1878474162730bcda0677b724b387ff9d74c8f3a3</citedby><cites>FETCH-LOGICAL-c353t-d14171a4f3fd341877c17afa1878474162730bcda0677b724b387ff9d74c8f3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30407512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bapistella, Sascha</creatorcontrib><creatorcontrib>Hamprecht, Klaus</creatorcontrib><creatorcontrib>Thomas, Wolfgang</creatorcontrib><creatorcontrib>Speer, Christian P</creatorcontrib><creatorcontrib>Dietz, Klaus</creatorcontrib><creatorcontrib>Maschmann, Jens</creatorcontrib><creatorcontrib>Poets, Christian F</creatorcontrib><creatorcontrib>Goelz, Rangmar</creatorcontrib><title>Short-term Pasteurization of Breast Milk to Prevent Postnatal Cytomegalovirus Transmission in Very Preterm Infants</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Postnatally acquired cytomegalovirus (pCMV) infection through breast milk (BM) may cause severe illness and even death, yet BM is advantageous for preterm infants. Therefore, effective methods to prevent CMV transmission are needed.
To assess the effectiveness of short-term pasteurization (62°C for 5 seconds) in preventing CMV transmission via BM in preterm infants. Design: Prospective interventional bicentric cohort study with infant enrollment between 6/2010 and 1/2012. A cohort from the Tuebingen neonatal intensive care unit (NICU) from 1995-1998 served as historical controls. Differences in CMV transmission were compared with reference to the cumulative time at risk for CMV transmission. Setting: Two German level-3 NICUs. Eighty-seven preterm infants of 69 CMV immunoglobulin G-positive mothers with birth weight <1500 g or gestational age <32 weeks and 83 historical controls were included. Intervention: BM samples were short-term pasteurized from postnatal day 4 to discharge. Primary endpoint: CMV status at discharge, evaluated by polymerase chain reaction and short-term microculture from urine.
Two of 87 (2.3%) study infants had a pCMV transmission. This compared to 17 of 83 (20.5%) controls. Total time under risk for infection was 9.6 years vs 10.0 years in controls, yielding an incidence of 0.21/year (95% confidence interval [CI], 0.03 to 0.75/year) vs 1.70/year (95% CI, 0.99 to 2.72/year), respectively. The risk ratio controls vs study infants was 8.3 (95% CI, 2.4 to 52.4) according to Cox proportional hazard model (P = .0003).
Short-term pasteurization significantly reduces the incidence of pCMV infection through BM in the NICU.
NCT01178905.</description><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNo9kF1LwzAUhoMobk5v_AGSSxGqSZM26aUOPwYTB05vS9omGm2TmaSD-uvN3PTicA6H57wcHgBOMbrEqCBXtW5iDQXN9sAYZ4QleVbg_TijjCeUEz4CR95_IIQxR9khGBFEEctwOgbu-d26kATpOrgQPsje6W8RtDXQKnjjZNzBR91-wmDhwsm1NAEurA9GBNHC6RBsJ99Ea9fa9R4unTC-095vArSBr9INm7Pf_JlRwgR_DA6UaL082fUJeLm7XU4fkvnT_Wx6PU9qkpGQNJhihgVVRDWEYs5YjZlQIk6cMorzlBFU1Y1AOWMVS2lFOFOqaBituSKCTMD5Nnfl7FcvfSjjY7VsW2Gk7X2ZYoJTwnLEI3qxRWtnvXdSlSunO-GGEqNy47iMjsut4wif7XL7qpPNP_onlfwABQV57A</recordid><startdate>20190718</startdate><enddate>20190718</enddate><creator>Bapistella, Sascha</creator><creator>Hamprecht, Klaus</creator><creator>Thomas, Wolfgang</creator><creator>Speer, Christian P</creator><creator>Dietz, Klaus</creator><creator>Maschmann, Jens</creator><creator>Poets, Christian F</creator><creator>Goelz, Rangmar</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190718</creationdate><title>Short-term Pasteurization of Breast Milk to Prevent Postnatal Cytomegalovirus Transmission in Very Preterm Infants</title><author>Bapistella, Sascha ; Hamprecht, Klaus ; Thomas, Wolfgang ; Speer, Christian P ; Dietz, Klaus ; Maschmann, Jens ; Poets, Christian F ; Goelz, Rangmar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-d14171a4f3fd341877c17afa1878474162730bcda0677b724b387ff9d74c8f3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bapistella, Sascha</creatorcontrib><creatorcontrib>Hamprecht, Klaus</creatorcontrib><creatorcontrib>Thomas, Wolfgang</creatorcontrib><creatorcontrib>Speer, Christian P</creatorcontrib><creatorcontrib>Dietz, Klaus</creatorcontrib><creatorcontrib>Maschmann, Jens</creatorcontrib><creatorcontrib>Poets, Christian F</creatorcontrib><creatorcontrib>Goelz, Rangmar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bapistella, Sascha</au><au>Hamprecht, Klaus</au><au>Thomas, Wolfgang</au><au>Speer, Christian P</au><au>Dietz, Klaus</au><au>Maschmann, Jens</au><au>Poets, Christian F</au><au>Goelz, Rangmar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term Pasteurization of Breast Milk to Prevent Postnatal Cytomegalovirus Transmission in Very Preterm Infants</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2019-07-18</date><risdate>2019</risdate><volume>69</volume><issue>3</issue><spage>438</spage><epage>444</epage><pages>438-444</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><abstract>Postnatally acquired cytomegalovirus (pCMV) infection through breast milk (BM) may cause severe illness and even death, yet BM is advantageous for preterm infants. Therefore, effective methods to prevent CMV transmission are needed.
To assess the effectiveness of short-term pasteurization (62°C for 5 seconds) in preventing CMV transmission via BM in preterm infants. Design: Prospective interventional bicentric cohort study with infant enrollment between 6/2010 and 1/2012. A cohort from the Tuebingen neonatal intensive care unit (NICU) from 1995-1998 served as historical controls. Differences in CMV transmission were compared with reference to the cumulative time at risk for CMV transmission. Setting: Two German level-3 NICUs. Eighty-seven preterm infants of 69 CMV immunoglobulin G-positive mothers with birth weight <1500 g or gestational age <32 weeks and 83 historical controls were included. Intervention: BM samples were short-term pasteurized from postnatal day 4 to discharge. Primary endpoint: CMV status at discharge, evaluated by polymerase chain reaction and short-term microculture from urine.
Two of 87 (2.3%) study infants had a pCMV transmission. This compared to 17 of 83 (20.5%) controls. Total time under risk for infection was 9.6 years vs 10.0 years in controls, yielding an incidence of 0.21/year (95% confidence interval [CI], 0.03 to 0.75/year) vs 1.70/year (95% CI, 0.99 to 2.72/year), respectively. The risk ratio controls vs study infants was 8.3 (95% CI, 2.4 to 52.4) according to Cox proportional hazard model (P = .0003).
Short-term pasteurization significantly reduces the incidence of pCMV infection through BM in the NICU.
NCT01178905.</abstract><cop>United States</cop><pmid>30407512</pmid><doi>10.1093/cid/ciy945</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1058-4838 |
ispartof | Clinical infectious diseases, 2019-07, Vol.69 (3), p.438-444 |
issn | 1058-4838 1537-6591 |
language | eng |
recordid | cdi_proquest_miscellaneous_2131237608 |
source | Oxford Academic |
title | Short-term Pasteurization of Breast Milk to Prevent Postnatal Cytomegalovirus Transmission in Very Preterm Infants |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T03%3A27%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Short-term%20Pasteurization%20of%20Breast%20Milk%20to%20Prevent%20Postnatal%20Cytomegalovirus%20Transmission%20in%20Very%20Preterm%20Infants&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Bapistella,%20Sascha&rft.date=2019-07-18&rft.volume=69&rft.issue=3&rft.spage=438&rft.epage=444&rft.pages=438-444&rft.issn=1058-4838&rft.eissn=1537-6591&rft_id=info:doi/10.1093/cid/ciy945&rft_dat=%3Cproquest_cross%3E2131237608%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c353t-d14171a4f3fd341877c17afa1878474162730bcda0677b724b387ff9d74c8f3a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2131237608&rft_id=info:pmid/30407512&rfr_iscdi=true |