Short-term Pasteurization of Breast Milk to Prevent Postnatal Cytomegalovirus Transmission in Very Preterm Infants

Postnatally acquired cytomegalovirus (pCMV) infection through breast milk (BM) may cause severe illness and even death, yet BM is advantageous for preterm infants. Therefore, effective methods to prevent CMV transmission are needed. To assess the effectiveness of short-term pasteurization (62°C for...

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Bibliographic Details
Published in:Clinical infectious diseases 2019-07, Vol.69 (3), p.438-444
Main Authors: Bapistella, Sascha, Hamprecht, Klaus, Thomas, Wolfgang, Speer, Christian P, Dietz, Klaus, Maschmann, Jens, Poets, Christian F, Goelz, Rangmar
Format: Article
Language:English
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Summary:Postnatally acquired cytomegalovirus (pCMV) infection through breast milk (BM) may cause severe illness and even death, yet BM is advantageous for preterm infants. Therefore, effective methods to prevent CMV transmission are needed. To assess the effectiveness of short-term pasteurization (62°C for 5 seconds) in preventing CMV transmission via BM in preterm infants. Design: Prospective interventional bicentric cohort study with infant enrollment between 6/2010 and 1/2012. A cohort from the Tuebingen neonatal intensive care unit (NICU) from 1995-1998 served as historical controls. Differences in CMV transmission were compared with reference to the cumulative time at risk for CMV transmission. Setting: Two German level-3 NICUs. Eighty-seven preterm infants of 69 CMV immunoglobulin G-positive mothers with birth weight
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciy945