Impact of age on elderly patients with oral cancer

Introduction In this study we have tried to analyze the impact of age on various clinico-pathological parameters, treatment completion and subsequent survival in older patients. Materials and methods This is a retrospective analysis of 140 elderly (> 65 years) patients of oral cancer operated bet...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2019-01, Vol.276 (1), p.223-231
Main Authors: Malik, Akshat, Mishra, Aseem, Chopda, Prashant, Singhvi, Hitesh, Nair, Sudhir, Nair, Deepa, Laskar, Sarbani Ghosh, Prabhash, Kumar, Agarwal, Jai Prakash, Chaturvedi, Pankaj
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Chi-Square Distribution
Combined Modality Therapy
Female
Head & Neck
Head and Neck Surgery
Humans
Male
Medicine
Medicine & Public Health
Mouth Neoplasms - diagnosis
Mouth Neoplasms - mortality
Mouth Neoplasms - pathology
Mouth Neoplasms - therapy
Multivariate Analysis
Neurosurgery
Otorhinolaryngology
Prognosis
Retrospective Studies
Survival Analysis
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Summary:Introduction In this study we have tried to analyze the impact of age on various clinico-pathological parameters, treatment completion and subsequent survival in older patients. Materials and methods This is a retrospective analysis of 140 elderly (> 65 years) patients of oral cancer operated between January 2012 and December 2013. The patients were divided into two groups based upon their age that ≤ 70 years and > 70 years.Association of distribution of various clinico-pathological factors between different groups was assessed by using Chi-square test. Survival analysis was done using Kaplan Meir analysis. Univariate and multivariate analysis were performed. Results The two groups had similar distribution of various clinico-pathological factors. Disease free survival for the group ≤ 70 and > 70 years was 37.6 months and 36.4 months ( p   70 years and ≤ 70 years were either advised or received sub-optimal adjuvant therapy ( p   70 years of age. Age did not affect survival. Majority of patients could complete the adjuvant therapy advised. Still, significantly more number of patients > 70 years could not receive/complete appropriate adjuvant therapy. Thus treatment needs to be tailored keeping in mind the individual’s performance status and the co-morbidities.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-018-5191-1