Effects of Agaricus brasiliensis mushroom in Walker-256 tumor-bearing rats

Agaricus brasiliensis is a mushroom native to São Paulo State, Brazil, that is studied for its medicinal proprieties. This work aimed to investigate the antitumoral activity of A. brasiliensis extracts and pure powdered basidiocarp preparation using Walker-256 (W256) tumor-bearing rats, a model for...

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Published in:Canadian journal of physiology and pharmacology 2010-01, Vol.88 (1), p.21-27
Main Authors: Jumes, Fernanda Menon Dias, Lugarini, Daiana, Pereira, Amanda Leite Bastos, de Oliveira, Anabel, Christoff, Adriana de Oliveira, Linde, Giani Andrea, do Valle, Juliana Silveira, Colauto, Nelson Barros, Acco, Alexandra
Format: Article
Language:English
Subjects:
Agaricus
Agaricus blazei
Agaricus brasiliensis
Animals
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Antioxidants
Biological and medical sciences
Carcinoma 256, Walker - drug therapy
Carcinoma 256, Walker - metabolism
foie
Fundamental and applied biological sciences. Psychology
liver
Male
Mushrooms
oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Phytotherapy - methods
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats
Rats, Wistar
stress oxydatif
Studies
tumeur
tumeur Walker-256
tumor
Tumors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Walker-256
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Summary:Agaricus brasiliensis is a mushroom native to São Paulo State, Brazil, that is studied for its medicinal proprieties. This work aimed to investigate the antitumoral activity of A. brasiliensis extracts and pure powdered basidiocarp preparation using Walker-256 (W256) tumor-bearing rats, a model for cancer-related cachexia studies. The rats were treated for 14 days by gavage (136 mg/kg) and at the end of the experiment tumors were collected to calculate mass and volume. Blood was collected for determination of plasma glucose, albumin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Hepatic and tumor enzymes indicating oxidative stress were also evaluated. The results showed that all 4 treatments (pure powdered basidiocarp and aqueous, acid, and alkaline extracts) significantly reduced tumor size and promoted gain in body weight. Plasmatic analysis showed a reduction in AST level and increased glycemia in the treated rats. Pure basidiocarp preparations improved the liver catalase and superoxide dismutase activity, but did not change the glutathione S-transferase activity. The data collected from the W256 tumor-bearing rats revealed the beneficial effects of A. brasiliensis in tumor treatment, mainly related to cachexia. The benefits can be partly related to antioxidant activity and to reduction of weight loss and tumor growth.
ISSN:0008-4212
1205-7541
DOI:10.1139/Y09-111