Homogeneous enzyme-free and entropy-driven isothermal fluorescent assay for nucleic acids based on a dual-signal output amplification strategy

Herein, we developed a homogeneous enzyme-free, ultrasensitive and isothermal fluorescent biosensor for nucleic acid detection with dual-signal output to enhance the reaction rate and sensitivity by combining an entropy-driven catalysis strategy with a catalytic hairpin assembly reaction.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-11, Vol.54 (89), p.12594-12597
Main Authors: Xiong, Erhu, Zhen, Deshuai, Jiang, Ling
Format: Article
Language:English
Subjects:
Biosensing Techniques
Biosensors
Catalysis
Entropy
Enzymes
Fluorescence
Nucleic Acid Amplification Techniques
Nucleic acids
Nucleic Acids - analysis
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Description
Summary:Herein, we developed a homogeneous enzyme-free, ultrasensitive and isothermal fluorescent biosensor for nucleic acid detection with dual-signal output to enhance the reaction rate and sensitivity by combining an entropy-driven catalysis strategy with a catalytic hairpin assembly reaction.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07508e