Antiphospholipid antibodies associated with nodal marginal zone lymphoma and its progression to diffuse large B-cell lymphoma—A case report

An association between autoimmune events, as well as the development of antiphospholipid (aPL) antibodies and lymphoproliferative disorders is well recognized. We present the patient with coagulation abnormalities and non-Hodgkin lymphoma (NHL), primarily diagnosed as nodal marginal zone B-cell lymp...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2019-01, Vol.215 (1), p.222-228
Main Authors: Belančić, Andrej, Vranić, Luka, Ševeljević, Ivan, Hadžisejdić, Ita, Načinović, Antica Duletić, Jonjić, Nives
Format: Article
Language:English
Subjects:
Anti-β2-glycoprotein I antibodies
Antiphospholipid antibody
Lupus anticoagulant
Nodal marginal zone lymphoma
Non-Hodgkin lymphoma
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Summary:An association between autoimmune events, as well as the development of antiphospholipid (aPL) antibodies and lymphoproliferative disorders is well recognized. We present the patient with coagulation abnormalities and non-Hodgkin lymphoma (NHL), primarily diagnosed as nodal marginal zone B-cell lymphoma (NMZL), and in relapse as diffuse large B-cell lymphoma (DLBCL). In the follow-up period, the patient simultaneously developed different aPL antibodies. The presence of aPL antibodies in NHL is frequent but it is not common in the NMZL. The aim of the present case report is to highlight the possible underlying increase of aPL antibodies in NMZL patients with coagulation tests abnormalities.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2018.10.020