Hydroxyapatite nanorods loaded with parathyroid hormone (PTH) synergistically enhance the net formative effect of PTH anabolic therapy

Parathyroid hormone (PTH) has been a major contributor to the anabolic therapy for osteoporosis, but its delivery to bone without losing activity and avoiding adverse local effects remain a challenge. Being the natural component of bone, use of hydroxyapatite for this purpose brings a major breakthr...

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Bibliographic Details
Published in:Nanomedicine 2019-01, Vol.15 (1), p.218-230
Main Authors: Dave, Jay R., Dewle, Ankush M., Mhaske, Suhas T., Phulpagar, Prashant T., Mathe, Vikas L., More, Supriya E., Khan, Ayesha A., Murthy, Appala Venkata Ramana, Datar, Suwarna S., Jog, Ajay J., Page, Megha, Tomar, Geetanjali B.
Format: Article
Language:English
Subjects:
Hydroxyapatite nanorod
Nanocarrier
Osteoporosis
Parathyroid hormone (PTH (1-34))
Synergistic anabolism
Targeted delivery
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Summary:Parathyroid hormone (PTH) has been a major contributor to the anabolic therapy for osteoporosis, but its delivery to bone without losing activity and avoiding adverse local effects remain a challenge. Being the natural component of bone, use of hydroxyapatite for this purpose brings a major breakthrough in synergistic anabolism. This study focuses on synthesis, characterization and evaluation of in vitro and in vivo efficacy of PTH (1-34) adsorbed hydroxyapatite nanocarrier for synergistic enhancement in the anabolic activity of PTH for bone regeneration. The negative zeta potential of this nanocarrier facilitated its affinity to the Ca2+ rich bone tissue and solubilization at low pH enhanced specific delivery of PTH to the resorption pits in osteoporotic bone. In this process, PTH retained its anabolic effect and at the same time an increase in bone mineral content indicated enhancement of the net formative effect of the PTH anabolic therapy. [Display omitted]
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2018.10.003