Low-dose recombinant canine interferon-g for treatment of canine atopic dermatitis: An open randomized comparative trial of two doses

The purpose of this study was to investigate the minimum effective dose of recombinant canine interferon-g (rCaIFN-g) for the treatment of dogs with atopic dermatitis (AD). Thirty-four dogs with AD from 17 animal hospitals in Japan were administered half or one-fifth of the approved rCaIFN-g dose of...

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Published in:Veterinary dermatology 2010-02, Vol.21 (1), p.42-49
Main Authors: Yasukawa, Kuniyoshi, Saito, Shiori, Kubo, Takuya, Shibasaki, Yuya, Yamaoka, Kayo, Hachimura, Hisae, Kuyama, Tomoko, Amimoto, Akiteru, Kumata, Tsuyoshi, Kitahara, Yuko, Takenaka, Masahiko, Matsumura, Hitoshi, Uno, Takehiro, Uchino, Tomiya, Takehara, Kazutaka, Nishida, Kouji, Kadoya, Michiyo, Sato, Masafumi, Kato, Kaoru, Matsumoto, Kanako, Saito, Satoshi, Shimoda, Tetsuya
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Language:English
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Summary:The purpose of this study was to investigate the minimum effective dose of recombinant canine interferon-g (rCaIFN-g) for the treatment of dogs with atopic dermatitis (AD). Thirty-four dogs with AD from 17 animal hospitals in Japan were administered half or one-fifth of the approved rCaIFN-g dose of 10 000 units/kg, three times a week for 4 weeks, followed by once weekly for an additional 4 weeks. Pruritus, excoriation, erythema and alopecia were evaluated and scored by the investigators on weeks 2, 4, 6, 8 and 12. The efficacy rate (number of excellent cases + number of good cases/total number of cases) at week 8 in the 2000 units/kg group was 36.4% for pruritus, 36.4% for excoriation, 45.5% for erythema and 36.4% for alopecia. In contrast, in the 5000 units/kg group, the efficacy rate was 64.3% for pruritus, 57.1% for excoriation, 78.6% for erythema and 78.6% for alopecia. The efficacy rate of the 5000 units/kg group was high for all signs evaluated and comparable to that of the 10 000 units/kg group reported in a previous study. The results of this study showed that 2000 units/kg of rCaIFN-g is less effective than 5000 units/kg to treat dogs with AD, and the efficacy of the 5000 units/kg dose is comparable to that of 10 000 units/kg at week 8.
ISSN:0959-4493
DOI:10.1111/j.1365-3164.2009.00764.x