Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin

Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disease. The present study investigated the effects of 50 and 100 mg/kg berberine (BRB) on recognition memory, oxidative stress, and purinergic neurotransmission, in a model of sporadic dementia of the Alzheimer’s type indu...

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Bibliographic Details
Published in:Psychopharmacology 2019-02, Vol.236 (2), p.641-655
Main Authors: de Oliveira, Juliana Sorraila, Abdalla, Fátima Husein, Dornelles, Guilherme Lopes, Palma, Taís Vidal, Signor, Cristiane, da Silva Bernardi, Jamile, Baldissarelli, Jucimara, Lenz, Luana Suéling, de Oliveira, Vitor Antunes, Chitolina Schetinger, Maria Rosa, Melchiors Morsch, Vera Maria, Rubin, Maribel Antonello, de Andrade, Cinthia Melazzo
Format: Article
Language:English
Subjects:
5'-Nucleotidase - drug effects
5'-Nucleotidase - metabolism
Adenosine
Adenosine deaminase
Adenosine Deaminase - drug effects
Adenosine Deaminase - metabolism
Advertising executives
Alzheimer Disease - psychology
Alzheimer's disease
Animals
Antibiotics, Antineoplastic - toxicity
Antioxidants
Antioxidants (Nutrients)
Berberine
Berberine - pharmacology
Biomedical and Life Sciences
Biomedicine
Brain
Brain - drug effects
Brain - metabolism
Care and treatment
Causes of
Cellular signal transduction
Cerebral cortex
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Complications and side effects
Dehydration
Dementia disorders
Disease Models, Animal
Glutathione
Glutathione transferase
Glutathione Transferase - drug effects
Glutathione Transferase - metabolism
Health aspects
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Impairment
Injection
Injections, Intraventricular
Lipid Metabolism - drug effects
Lipid peroxidation
Male
Medical research
Memory
Memory - drug effects
Memory disorders
Memory Disorders - chemically induced
Nervous system diseases
Neuroprotection
Neuroprotective Agents - pharmacology
Neurosciences
Neurotransmission
Nucleosides
Nucleotidase
Nucleotidases
Original Investigation
Oxidation
Oxidation-Reduction - drug effects
Oxidation-reduction reactions
Oxidative stress
Oxidative Stress - drug effects
Pharmacology/Toxicology
Physiological aspects
Prevention
Psychiatry
Purine nucleotides
Pyrophosphatases - drug effects
Pyrophosphatases - metabolism
Rats
Rats, Wistar
Reactive oxygen species
Reactive Oxygen Species - metabolism
Recognition (Psychology) - drug effects
Rodents
Streptozocin
Streptozocin - toxicity
Sulfur compounds
Synaptosomes
Synaptosomes - drug effects
Synaptosomes - enzymology
Thiols
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Summary:Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disease. The present study investigated the effects of 50 and 100 mg/kg berberine (BRB) on recognition memory, oxidative stress, and purinergic neurotransmission, in a model of sporadic dementia of the Alzheimer’s type induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats. Rats were submitted to ICV-STZ 3 mg/kg or saline, and 3 days later, were started on a treatment of BRB or saline for 21 days. The results demonstrated that BRB was effective in protecting against memory impairment, increased reactive oxygen species, and the subsequent increase in protein and lipid oxidation in the cerebral cortex and hippocampus, as well as δ-aminolevulinate dehydratase inhibition in the cerebral cortex. Moreover, the decrease in total thiols, and the reduced glutathione and glutathione S-transferase activity in the cerebral cortex and hippocampus of ICV-STZ rats, was prevented by BRB treatment. Besides an antioxidant effect, BRB treatment was capable of preventing decreases in ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), 5′-nucleotidase (EC-5’-Nt), and adenosine deaminase (ADA) activities in synaptosomes of the cerebral cortex and hippocampus. Thus, our data suggest that BRB exerts a neuroprotective effect on recognition memory, as well as on oxidative stress and oxidative stress-related damage, such as dysfunction of the purinergic system. This suggests that BRB may act as a promising multipotent agent for the treatment of AD.
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-018-5090-6