Prognostic significance of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in diffuse large B cell lymphoma

Aberrant monocyte chemoattractant protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) expression in malignant tissues have been reported; however, their role in hematological malignancies prognosis remains little known. The aim of this study was to investigate the prognostic value of MCP-1 and CCR2...

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Bibliographic Details
Published in:Annals of hematology 2019-02, Vol.98 (2), p.413-422
Main Authors: Li, Yan-Li, Shi, Zhi-Hu, Wang, Xian, Gu, Kang-Sheng, Zhai, Zhi-min
Format: Article
Language:English
Subjects:
Chemokines
Hematology
Lymphoma
Medical prognosis
Medicine
Medicine & Public Health
Monoclonal antibodies
Oncology
Original Article
Targeted cancer therapy
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Summary:Aberrant monocyte chemoattractant protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) expression in malignant tissues have been reported; however, their role in hematological malignancies prognosis remains little known. The aim of this study was to investigate the prognostic value of MCP-1 and CCR2 expression in patients with diffuse large B cell lymphoma (DLBCL). The study included 221 patients with DLBCL. MCP-1 and CCR2 expression was analyzed by immunohistochemical staining and its correlations with clinicopathologic features and prognosis were evaluated. High expression of MCP-1 or CCR2 was correlated with clinicopathological characteristics, and an adverse prognostic factor for overall survival (OS) and progression-free survival (PFS) of DLBCL patients. Also, significant positive correlation between MCP-1 and CCR2 expression was revealed ( r  = 0.545, P  
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-018-3522-3