Dendritic cells and Th17/Treg ratio play critical roles in pathogenic process of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a common disorder of respiratory system. This study aimed to evaluate changes of mature dendritic cells (DCs) and regulatory T cells (Treg) in lung tissues and peripheral blood of COPD patients. For lung tissue analysis, patients were divided into no-s...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2018-12, Vol.108, p.1141-1151
Main Authors: Zheng, Xiangru, Zhang, Lanying, Chen, Jie, Gu, Yanhui, Xu, Jingqing, Ouyang, Yao
Format: Article
Language:English
Subjects:
B7-1 Antigen - metabolism
Chronic obstructive pulmonary disease
Dendritic cells
Dendritic Cells - immunology
Female
Forced Expiratory Volume
Forkhead Transcription Factors - metabolism
Humans
Interleukin-17 - metabolism
Lung - pathology
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - immunology
Pulmonary Disease, Chronic Obstructive - pathology
Pulmonary Disease, Chronic Obstructive - physiopathology
Receptors, CCR6 - metabolism
Regulatory T cells
Smoking
T-Lymphocytes, Regulatory - immunology
Th17 Cells - immunology
Th17/Treg
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic obstructive pulmonary disease (COPD) is a common disorder of respiratory system. This study aimed to evaluate changes of mature dendritic cells (DCs) and regulatory T cells (Treg) in lung tissues and peripheral blood of COPD patients. For lung tissue analysis, patients were divided into no-smoking and no-COPD (CS-COPD-), smoking and no-COPD (CS + COPD-) and COPD group. For peripheral blood analysis, patients were divided into CS-COPD-, CS + COPD-, stable COPD (SCOPD) and acute exacerbation of COPD (AECOPD) group. Hematoxylin and eosin (HE) staining was used to evaluate inflammation of lung tissues. Immunohistochemistry assay was employed to examine CD80, CCR6, IL-17 A, FoxP3 in lung tissues. DCs and Treg cells were isolated from lung tissues and peripheral blood. Levels of CD80, FoxP3+ Treg, CCR6 and IL-17 A were detected by using flow cytometry. Results showed that FEV%, FVC% and FEV1/FVC were significantly reduced and Bosken scores were remarkably increased in COPD patients compared to non-COPD patients (p 
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2018.09.113