Exercise responsive micro ribonucleic acids identify patients with coronary artery disease

Abstract Aims Exercise is a trigger for acute coronary events especially in the untrained. Identifying subjects at risk remains a challenge. We set out to assess whether a distinct pattern of micro ribonucleic acids (miRNAs) expressed in response to an acute bout of all-out exercise might exist that...

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Published in:European journal of preventive cardiology 2019-03, Vol.26 (4), p.348-355
Main Authors: Mayr, Barbara, Müller, Edith E, Schäfer, Christine, Droese, Silke, Breitenbach-Koller, Hannelore, Schönfelder, Martin, Niebauer, Josef
Format: Article
Language:English
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Summary:Abstract Aims Exercise is a trigger for acute coronary events especially in the untrained. Identifying subjects at risk remains a challenge. We set out to assess whether a distinct pattern of micro ribonucleic acids (miRNAs) expressed in response to an acute bout of all-out exercise might exist that would allow discrimination between health and disease. Methods Twenty healthy subjects and 20 patients with coronary artery disease (CAD) performed an all-out cycle ergometry. Total RNA was extracted from blood drawn before and after exercise. Each blood sample was analysed for 187 target miRNAs by quantitative reverse transcription polymerase chain reaction. Results At baseline, 18 miRNAs allowed discrimination between healthy subjects and CAD patients. In response to an acute all-out exercise in healthy subjects 51 miRNAs and in CAD patients 60 miRNAs were significantly modulated (all p 
ISSN:2047-4873
2047-4881
DOI:10.1177/2047487318808014