Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma

Purpose Adenoid cystic carcinoma (ACC) is an intriguing lesion because it shows a slow growth in the beginning, but a late poor prognosis due to perineural invasion, metastasis and recurrence. This study aimed to investigate whether Akt signaling would be deregulated in adenoid cystic carcinoma and...

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Published in:European archives of oto-rhino-laryngology 2018-12, Vol.275 (12), p.3039-3047
Main Authors: Branco, Karla Flaviana Carneiro Castelo, Ribeiro, Andre Luis Ribeiro, de Mendonça, Raíssa Pinheiro, de Jesus Viana Pinheiro, João, da Silva Kataoka, Maria Sueli, Arnaud, Maria Vanda Catão, de Melo Alves Junior, Sérgio
Format: Article
Language:English
Subjects:
Adenoma, Pleomorphic - metabolism
Adenoma, Pleomorphic - pathology
beta Catenin - metabolism
Carcinoma, Adenoid Cystic - metabolism
Carcinoma, Adenoid Cystic - pathology
Cyclin D1 - metabolism
Cyclooxygenase 2 - metabolism
Head & Neck
Head and Neck Surgery
Humans
Immunohistochemistry
Medicine
Medicine & Public Health
Neurosurgery
NF-kappa B p50 Subunit - metabolism
Otorhinolaryngology
Proto-Oncogene Proteins c-akt - metabolism
Salivary Gland Neoplasms - metabolism
Salivary Gland Neoplasms - pathology
Salivary Glands - pathology
Signal Transduction
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Summary:Purpose Adenoid cystic carcinoma (ACC) is an intriguing lesion because it shows a slow growth in the beginning, but a late poor prognosis due to perineural invasion, metastasis and recurrence. This study aimed to investigate whether Akt signaling would be deregulated in adenoid cystic carcinoma and its consequence in the expression of associated proteins. Methods The expression of the Akt, p-Akt, NFκB, β-catenin, cyclin D1 and COX-2 was assessed by immunohistochemistry in 10 cases of ACC, 17 cases of pleomorphic adenoma (PA), and 7 cases of normal salivary gland (NSG). Results p-Akt was overexpressed in ACC when compared to NSG. NFκB, β-catenin, and COX-2 were overexpressed in ACC and PA when compared to NSG. Most proteins were slightly higher expressed in ACC than in PA, but they never reached significance. p-Akt expression positively correlated with NFκB, β-catenin, cyclin D1 and COX-2 in ACC and PA, while this correlation trended to be negative in for these proteins (except for NFκB) in NSG using Person’s correlation analysis, but without reaching significance. Conclusions Our results indicate an abnormal activation of Akt signaling pathway, which can be an important regulator of tumor biology in ACC. Activated Akt correlated with the expression of NFκB, β-catenin and COX-2, which can potentially influence cell survival in ACC.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-018-5182-2