Relevance of electroencephalogram assessment in amyloid and tau pathology in rat

•The rats express in hippocampus beta-amyloid deposits and phosphorylated tau.•On the 3rd month, a working memory impairment is observed by Morris water maze test.•On the 3rd week, an overall decrease of the EEG bands power was observed, mainly theta waves during the REM.•EEG seems to be an interest...

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Bibliographic Details
Published in:Behavioural brain research 2019-02, Vol.359, p.127-134
Main Authors: Maleysson, Vincent, Page, Guylène, Janet, Thierry, Klein, Ronald L., Haida, Obélia, Maurin, Anne, Richard, Serge, Champeroux, Pascal, Fauconneau, Bernard
Format: Article
Language:English
Subjects:
Alzheimer Disease - diagnosis
Alzheimer Disease - physiopathology
Amyloid beta-Peptides - administration & dosage
Amyloid beta-Peptides - metabolism
Animals
Beta amyloid
Brain - physiopathology
Dependovirus - genetics
Disease Models, Animal
DNA Fingerprinting
Electroencephalography
Humans
Hymecromone
Male
Maze Learning - physiology
Memory, Short-Term - physiology
Peptide Fragments - administration & dosage
Peptide Fragments - metabolism
Phosphorylated tau
Phosphorylation
Rapid eye movement
Rats, Sprague-Dawley
Recombinant Proteins - administration & dosage
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Sleep, REM - physiology
tau Proteins - administration & dosage
tau Proteins - genetics
tau Proteins - metabolism
Theta waves
Water maze
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Summary:•The rats express in hippocampus beta-amyloid deposits and phosphorylated tau.•On the 3rd month, a working memory impairment is observed by Morris water maze test.•On the 3rd week, an overall decrease of the EEG bands power was observed, mainly theta waves during the REM.•EEG seems to be an interesting tool in the early diagnostic of amyloid and tau pathology. In order to contribute to a better knowledge on the relationship between amyloid and tau pathology, and electroencephalography (EEG) disturbances, the aim of this study was to evaluate the effects of injection of beta amyloid Abeta(1–42) peptide, tau (a recombinant AAV (Adeno-Associated Virus) containing the human transgene tau with the P301 L mutation on rats and the combination of both, on the power of brain’s rhythm (delta, theta, alpha, beta and gamma waves) during the different sleep/wake states of animals by EEG recording. Currently, no preclinical studies explore the effect of the tau pathology on EEG. The experimentations were performed 3 weeks and 3 months post injections. Beta amyloid deposits and hyperphosphorylated Tau are observed by immunohistofluorescence, only in the hippocampus. Furthermore, using a radial arm water maze, the main effect was observed on working memory which was significantly impaired in Abeta-Tau group only 3 months post injections. However, on EEG, as early as the 3rd week, an overall decrease of the EEG bands power was observed in the treated groups, particularly the theta waves during the rapid eye movement (REM) sleep. Beta amyloid was mainly involved in these perturbations. Obviously, EEG seems to be an interesting tool in the early diagnostic of amyloid and tau pathologies, with a good sensitivity and the possibility to perform a follow up during a large period.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2018.10.026