Urine concentrations changes of cysteinyl leukotrienes in non-obese children with obstructive sleep apnea undergoing adenotonsillectomy

The main objective of the study was to compare preoperative to postoperative levels of urine-Cysteinyl leukotrienes (uCysLT) in children undergoing adenotonsillectomy (AT) for obstructive sleep apnea (OSA) in order to investigate whether exaggerated leukotriene activity is the cause or consequence o...

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Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2018-12, Vol.115, p.149-152
Main Authors: Mousailidis, George Κ., Lachanas, Vasileios A., Vasdeki, Afroditi, Alexopoulos, Emmanuel I., Kaditis, Athanasios G., Petinaki, Efthymia, Balatsos, Nikolaos A.A., Bizakis, John G., Skoulakis, Charalampos E.
Format: Article
Language:English
Subjects:
Adenoidectomy - methods
Adenotonsillectomy
Child
Child, Preschool
Cysteine - urine
Female
Humans
Leukotrienes - urine
Male
OSA
Pediatric obstructive sleep apnea
Polysomnography
Polysomnography - methods
Postoperative Period
Prospective Studies
Sleep Apnea, Obstructive - surgery
Sleep Apnea, Obstructive - urine
Tonsillectomy - methods
Urine - chemistry
Urine cysteinyl leukotriene
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Summary:The main objective of the study was to compare preoperative to postoperative levels of urine-Cysteinyl leukotrienes (uCysLT) in children undergoing adenotonsillectomy (AT) for obstructive sleep apnea (OSA) in order to investigate whether exaggerated leukotriene activity is the cause or consequence of OSA. A prospective study was conducted on non-obese children (4–10 years old) referred for overnight PSG. Children with moderate/severe OSA treated with AT were included. A second PSG study performed 2 months postoperatively to confirm OSA resolution, and those with residual OSA were excluded. Morning urine specimens after both PSG studies were obtained and pre-operative uCysLT levels were compared to postoperative levels. 27 children fulfilled the criteria and underwent a post-operative PSG study with three exclusions for residual OSA (postop-AHI>2), so the study group consisted of 24 children (mean age: 5.7 ± 2.1 years). Mean preoperative and postoperative AHI was 10.96 ± 5.93 and 1.44 ± 0.56 respectively. Mean preop-uCysLT were 21.14 ± 4.65, while after AT they significantly reduced to 12.62 ± 2.67 (P 
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2018.10.002