Prognostic factors associated with uterine sarcomas: the experience of a single institution

Uterine sarcomas are infrequent and heterogeneous mesenchymal tumours, associated with aggressive characteristics and a poor clinical outcome. The aim of the study is to describe the prognostic factors associated with uterine sarcomas. The clinical records between 2000 and 2014 of women diagnosed wi...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2019-02, Vol.39 (2), p.231-236
Main Authors: Barquet-Muñoz, Salim Abraham, Isla-Ortiz, David, Montalvo-Esquivel, Gonzalo, Cantú-de-León, David, Salcedo-Hernández, Rosa Angélica, Cordoba-Gonzalez, Veronica, Herrera-Gómez, Ángel
Format: Article
Language:English
Subjects:
Adult
Cytoreduction
Female
histology
Humans
Medical prognosis
Mexico - epidemiology
Middle Aged
Prognosis
prognostic factors
Retrospective Studies
Sarcoma
Sarcoma - diagnosis
Sarcoma - mortality
Sarcoma - pathology
undifferentiated endometrial sarcomas
Uterine Neoplasms - diagnosis
Uterine Neoplasms - mortality
Uterine Neoplasms - pathology
uterine sarcomas
Uterus - pathology
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Summary:Uterine sarcomas are infrequent and heterogeneous mesenchymal tumours, associated with aggressive characteristics and a poor clinical outcome. The aim of the study is to describe the prognostic factors associated with uterine sarcomas. The clinical records between 2000 and 2014 of women diagnosed with uterine sarcomas and initially treated surgically were reviewed. A histological comparison was performed. The overall survival (OS) and disease-free survival (DFS) were calculated and compared. Seventy-three women had surgery (12.3% had endometrial stromal sarcomas, 24.7% undifferentiated endometrial sarcomas, 49.3% leiomyosarcomas and 13.7% other subtypes). Complete cytoreduction had a mean DFS of 25.1 months, while the incomplete cytoreduction averaged in a DFS of 4.33 months (p = .04). The median five-year OS with a complete cytoreduction was not reached; the incomplete cytoreduction OS was 10.1 months (p = .002). Our data suggests that undifferentiated endometrial sarcomas have the lowest DFS (p = .004); while OS was negatively influence by stage IV (p 
ISSN:0144-3615
1364-6893
DOI:10.1080/01443615.2018.1492529