Alpha cell function interacts with diet to modulate prediabetes and Type 2 diabetes

Alpha- and beta-cells dysfunction is implicated in the development of Type 2 diabetes mellitus (T2DM). We aimed to evaluate whether alpha- and beta-cell dysfunction may precede prediabetes (PreDM) and T2DM development. Furthermore, we explored the role of two healthy diets (Mediterranean and low-fat...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2018-12, Vol.62, p.247-256
Main Authors: Roncero-Ramos, Irene, Jimenez-Lucena, Rosa, Alcala-Diaz, Juan F., Vals-Delgado, Cristina, Arenas-Larriva, Antonio P., Rangel-Zuñiga, Oriol A., Leon-Acuña, Ana, Malagon, María M., Delgado-Lista, Javier, Perez-Martinez, Pablo, Ordovas, Jose M., Camargo, Antonio, Lopez-Miranda, Jose
Format: Article
Language:English
Subjects:
CORDIOPREV
Diabetes
Glucagon/insulin ratio
Low-fat diet
Mediterranean diet
Prediabetes
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Summary:Alpha- and beta-cells dysfunction is implicated in the development of Type 2 diabetes mellitus (T2DM). We aimed to evaluate whether alpha- and beta-cell dysfunction may precede prediabetes (PreDM) and T2DM development. Furthermore, we explored the role of two healthy diets (Mediterranean and low-fat diets) modulating these processes. We included 462 patients from the CORDIOPREV study without T2DM at baseline, of which 272 were PreDM. During follow-up, 107 patients developed T2DM (T2DM-incident group), 30 developed PreDM (PreDM-incident group), 86 regressed to normoglycemia (PreDM-regression group) and 29 patients remained without PreDM or T2DM criteria (control group), according to the American Diabetes Association diagnosis criteria. We measured glucose, insulin, glucagon and GLP-1 plasma levels in the OGTT performed at baseline and after 2 years of follow-up. Patients were randomized to consume two healthy diets, a Mediterranean (>35%) and a low-fat (
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2018.08.012