Relationship between expression of XRCC1 and tumor proliferation, migration, invasion, and angiogenesis in glioma

Summary Recently, XRCC1 polymorphisms were reported to be associated with glioma in Chinese population. However, only a few studies reported on the XRCC1 expression, and cancer progression. In this study, we investigated whether XRCC1 plays a role in glioma pathogenesis. Using the tissue microarray...

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Bibliographic Details
Published in:Investigational new drugs 2019-08, Vol.37 (4), p.646-657
Main Authors: Mei, Peng-jin, Bai, Jin, Miao, Fa-an, Li, Zhong-lin, Chen, Chen, Zheng, Jun-nian, Fan, Yue-chao
Format: Article
Language:English
Subjects:
Angiogenesis
Astrocytes
Astrocytes - metabolism
Brain
Brain - metabolism
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Brain tumors
Cell adhesion & migration
Cell cycle
Cell Line, Tumor
Cell migration
Cell Movement
Cell Proliferation
Cyclin D1
Female
G1 phase
Gelatinase A
Glioma
Glioma - genetics
Glioma - metabolism
Glioma - pathology
Glioma cells
Human Umbilical Vein Endothelial Cells - physiology
Humans
Male
Matrix Metalloproteinase 2 - metabolism
Medicine
Medicine & Public Health
Middle Aged
mRNA
Neovascularization, Pathologic
Oncology
Pathogenesis
Pharmacology/Toxicology
Preclinical Studies
Studies
Tissues
Tumor suppressor genes
Tumors
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
Wound Healing
X-ray Repair Cross Complementing Protein 1 - genetics
X-ray Repair Cross Complementing Protein 1 - metabolism
XRCC1 protein
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Summary:Summary Recently, XRCC1 polymorphisms were reported to be associated with glioma in Chinese population. However, only a few studies reported on the XRCC1 expression, and cancer progression. In this study, we investigated whether XRCC1 plays a role in glioma pathogenesis. Using the tissue microarray technology, we found that XRCC1 expression is significantly decreased in glioma compared with tumor adjacent normal brain tissue ( P  
ISSN:0167-6997
1573-0646
DOI:10.1007/s10637-018-0667-9