Multiple simultaneous head and neck cancers in Lynch syndrome: Case report and literature review

Head and neck cancers account for a significant proportion of reported malignancies in the United States; however, multiple concurrent primary malignancies from different sites are rare. We describe the case of a 44‐year‐old man simultaneously diagnosed with three independent head and neck malignanc...

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Bibliographic Details
Published in:The Laryngoscope 2018-12, Vol.128 (12), p.2759-2761
Main Authors: Feng, Allen L., Le, Amanda, Johnson, Daniel N., Varvares, Mark A.
Format: Article
Language:English
Subjects:
Case reports
Colorectal cancer
Genetic disorders
Head & neck cancer
Head and neck cancer
hereditary nonpolyposis colorectal cancer (HNPCC)
Lynch syndrome
Thyroid cancer
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Summary:Head and neck cancers account for a significant proportion of reported malignancies in the United States; however, multiple concurrent primary malignancies from different sites are rare. We describe the case of a 44‐year‐old man simultaneously diagnosed with three independent head and neck malignancies (adenocarcinoma in minor salivary gland, papillary thyroid carcinoma, and acinic cell carcinoma) in the setting of Lynch syndrome. To our knowledge, this is the first case of multiple head and neck malignancies arising simultaneously from Lynch syndrome. This case highlights the need for diligent workup in patients with hereditary conditions that predispose to malignancies. Laryngoscope, 128:2759–2761, 2018
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.27259