Association of TAFI gene polymorphisms with severity of coronary stenosis in stable coronary artery disease

Coronary stenosis is a consequence of atherosclerotic plaque progression that is associated with impaired fibrinolysis. Thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor 1 (PAI-1) are fibrinolysis inhibitors whose levels are influenced by acquired conditions and...

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Bibliographic Details
Published in:Thrombosis research 2018-11, Vol.171, p.171-176
Main Authors: Rattanawan, Chutima, Komanasin, Nantarat, Settasatian, Nongnuch, Settasatian, Chatri, Kukongviriyapan, Upa, Intharapetch, Pongsak, Senthong, Vichai
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis
Carboxypeptidase B2 - genetics
Coronary Artery Disease - genetics
Coronary Artery Disease - pathology
Coronary Stenosis - genetics
Coronary Stenosis - pathology
Disease Progression
Female
Fibrinolysis
Humans
Male
Middle Aged
Plaque, Atherosclerotic - genetics
Plaque, Atherosclerotic - pathology
Plasminogen activator inhibitor 1
Plasminogen Activator Inhibitor 1 - genetics
Polymorphism
Polymorphism, Single Nucleotide
Thrombin-activatable fibrinolysis inhibitor
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Summary:Coronary stenosis is a consequence of atherosclerotic plaque progression that is associated with impaired fibrinolysis. Thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor 1 (PAI-1) are fibrinolysis inhibitors whose levels are influenced by acquired conditions and by polymorphisms. This study therefore aimed to investigate the association of TAFI and PAI-1 gene polymorphisms with severity of coronary stenosis in subjects with stable coronary artery disease (CAD). A total of 327 subjects suspected with CAD who underwent a coronary angiogram were recruited. Gensini score was applied to stratify the severity of coronary stenosis. Based on the Gensini score, the subjects were categorized into low-medium (
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2018.10.001