Tissue Crosstalk in T1D: Is Insulin Special?

In a recent issue of Nature,Wan et al. (2018) show that glucose-stimulated β cells secrete insulin B chain peptides relevant to autoimmunity in type 1 diabetes. Peptides such as insulin B:12-20 are released into circulation, where they can be directly and broadly presented by antigen-presenting cell...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Mass.), 2018-09, Vol.49 (3), p.394-396
Main Authors:	Jamison, Braxton L., Haskins, Kathryn
Format:	Article
Language:	eng
Subjects:	Antigen presentation Antigen-presenting cells Autoimmunity Beta cells Crosstalk Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Immune system Insulin Lymphatic system Lymphocytes Mass spectrometry Microscopy Peptides Proteins Scientific imaging T cell receptors
Online Access:	Get full text
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Summary:	In a recent issue of Nature,Wan et al. (2018) show that glucose-stimulated β cells secrete insulin B chain peptides relevant to autoimmunity in type 1 diabetes. Peptides such as insulin B:12-20 are released into circulation, where they can be directly and broadly presented by antigen-presenting cells throughout the lymphatic system. In a recent issue of Nature, Wan et al. (2018) show that glucose-stimulated β cells secrete insulin B chain peptides relevant to autoimmunity in type 1 diabetes. Peptides such as insulin B:12-20 are released into circulation, where they can be directly and broadly presented by antigen-presenting cells throughout the lymphatic system.
ISSN:	1074-7613 1097-4180