Dynamic Hydrogels from Host–Guest Supramolecular Interactions

Hydrogel biomaterials are pervasive in biomedical use. Applications of these soft materials range from contact lenses to drug depots to scaffolds for transplanted cells. A subset of hydrogels is prepared from physical cross‐linking mediated by host–guest interactions. Host macrocycles, the most reco...

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Bibliographic Details
Published in:Macromolecular bioscience 2019-01, Vol.19 (1), p.e1800281-n/a
Main Authors: Mantooth, Siena M., Munoz‐Robles, Brizzia G., Webber, Matthew J.
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - therapeutic use
Biomaterials
Biomedical materials
Cells, Immobilized - transplantation
Chains (polymeric)
Complex formation
Contact lenses
Contact Lenses, Hydrophilic
Cyclodextrins - chemistry
Cyclodextrins - therapeutic use
drug delivery
Drug Delivery Systems - methods
External stimuli
Humans
Hydrogels
Hydrogels - chemistry
Hydrogels - therapeutic use
injectable biomaterials
Jamming
materials chemistry
Polymers
rheology
Rotaxanes
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Summary:Hydrogel biomaterials are pervasive in biomedical use. Applications of these soft materials range from contact lenses to drug depots to scaffolds for transplanted cells. A subset of hydrogels is prepared from physical cross‐linking mediated by host–guest interactions. Host macrocycles, the most recognizable supramolecular motif, facilitate complex formation with an array of guests by inclusion in their portal. Commonly, an appended macrocycle forms a complex with appended guests on another polymer chain. The formation of poly(pseudo)rotaxanes is also demonstrated, wherein macrocycles are threaded by a polymer chain to give rise to physical cross‐linking by secondary non‐covalent interactions or polymer jamming. Host–guest supramolecular hydrogels lend themselves to a variety of applications resulting from their dynamic properties that arise from non‐covalent supramolecular interactions, as well as engineered responsiveness to external stimuli. These are thus an exciting new class of materials. Host–guest interactions enable powerful hydrogel materials. With specific host–guest recognition, or by threading polymer chains to form poly(pseudo)rotaxanes, dynamic hydrogels are realized with a diversity of possible biomedical applications.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.201800281