192R Allele of Paraoxanase 1 (PON1) Gene as a New Marker for Susceptibility to Bladder Cancer

Background: The human body has a number of endogenous free-radical scavenging systems. Paraoxonase1 (PON1) is one of the enzymes involved in such systems. The purpose of this study was to investigate the relationship between bladder cancer and the polymorphism of PON1 which results in Q/R substituti...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2009-10, Vol.29 (10), p.4041-4046
Main Authors: ÖZTÜRK, Oguz, KAGNICI, Ömer F, ÖZTÜRK, Tülin, DURAK, Haydar, TÜZÜNER, Bora M, KISAKESEN, Halil I, CAKALIR, Canser, ISBIR, Turgay
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Aryldialkylphosphatase - genetics
Aryldialkylphosphatase - metabolism
Biological and medical sciences
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Tumors
Tumors of the urinary system
Urinary Bladder Neoplasms - enzymology
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - pathology
Urinary tract. Prostate gland
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: The human body has a number of endogenous free-radical scavenging systems. Paraoxonase1 (PON1) is one of the enzymes involved in such systems. The purpose of this study was to investigate the relationship between bladder cancer and the polymorphism of PON1 which results in Q/R substitution at codon 192. This is the first report of this polymorphism in bladder cancer. Patients and Methods: Seventy-six bladder cancer patients and 135 healthy controls took part in the study. DNA from paraffin-embedded tissues for patients and from blood cells for controls was extracted. The distribution of PON1 192 polymorphism was determined by Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) techniques. Results: There was significant difference in PON1 genotype frequencies (patients/controls QQ: 8/37, QR: 53/84, RR: 15/14, p=0.007) between the control and bladder cancer patients. Moreover, in patients there was significant association of the RR genotype of PON1 with invasive growth pattern (p=0.027), perineural invasion (p=0.016), distant metastasis (p
ISSN:0250-7005
1791-7530