Reduced lnterleukin-5 Production by Peripheral Cd4+ T Cells in Common Variable Immunodeficiency Patients

We evaluated the capacity of peripheral CD4+ T helper cells in four Common Variable Immunodeficiency (CVI) patients to secrete interleukin-4 (IL-4) and IL-5. While in control CD4+ T cells, stimulated via CD3 and cultured in presence of IL-2 or IL-15, a 10 fold increased production of IL-5 (146 plus...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2008-01, Vol.30 (4), p.679-686
Main Authors: Vecchio, GCD, Martire, B, Lassandro, G, Cecinati, V, De Mattia, D, Ciccarelli, M, Piacente, L, Giordano, P
Format: Article
Language:English
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Summary:We evaluated the capacity of peripheral CD4+ T helper cells in four Common Variable Immunodeficiency (CVI) patients to secrete interleukin-4 (IL-4) and IL-5. While in control CD4+ T cells, stimulated via CD3 and cultured in presence of IL-2 or IL-15, a 10 fold increased production of IL-5 (146 plus or minus 30; 142 plus or minus 25 pg/ml) was found, a 4 fold increment of this cytokine was, instead, detected in 3 out of 4 CVI patients (34 plus or minus 13; 39 plus or minus 12 pg/ml) (p < 0.05). In conclusion, the reduction of IL-5, involved in the late regulation of B cell differentiation into Ig-secreting plasma cells, may contribute to the defective antibody production in CVI patients.
ISSN:0892-3973
DOI:10.1080/08923970802278102