Blood flow forces liver growth

Increases in biomechanical forces in the liver's blood vessels have now been shown to activate two mechanosensitive proteins. The proteins trigger blood-vessel cells to deploy regenerative factors that drive liver growth.

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Bibliographic Details
Published in:Nature (London) 2018-10, Vol.562 (7725), p.42-43
Main Authors: Rabbany, Sina Y, Rafii, Shahin
Format: Article
Language:English
Subjects:
Biomechanics
Blood flow
Blood pressure
Collagen
Endothelium
Growth
Growth factors
Hemodynamics
Integrin beta1
Liver
Liver research
Medical research
Neovascularization
Phosphorylation
Physiological aspects
Proteins
Shear stress
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Description
Summary:Increases in biomechanical forces in the liver's blood vessels have now been shown to activate two mechanosensitive proteins. The proteins trigger blood-vessel cells to deploy regenerative factors that drive liver growth.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-018-06741-2