Anticancer activity and underlying mechanism of neogambogic acid

Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evid...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2018-09, Vol.16 (9), p.641-643
Main Authors: SUN, Rui, ZHANG, Hong-Ming, CHEN, Bao-An
Format: Article
Language:English
Subjects:
Animals
Anticancer
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - chemistry
Chinese medicine
Garcinia - chemistry
Humans
Mechanism
Neogambogic acid
Neoplasms - drug therapy
Plant Extracts - administration & dosage
Plant Extracts - chemistry
Xanthenes - administration & dosage
Xanthenes - chemistry
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Summary:Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that the main active monomer gambogic acid isolated from garcinia can inhibit the growth of various cancer cells. Neogambogic acid is an isolated compound with a similar chemical structure as gambogic acid. Preliminary studies show that the neogambogic acid can selectively inhibit the growth of various cancer cells, and has a broader antitumor activity and lower toxicity than gambogic acid. In this review, we summarize the advances made in the investigation of the anti-tumor effect of neogambogic acid in recent years.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(18)30103-1