Synthesis, Spectral Characterization, and DNA Binding Studies of trans-[Dichlorobis(2,3-dicyanodipyrido-N super(8,9)-[3,2-f:2,3-h]quinoxaline)ch romium(III)] Perchlorate Dihydrate

A new dichlorochromium(III) complex with the 2,3- dicyanodipyridoquinoxaline ligand has been synthesized and characterized by UV-visible, mass spectroscopy, and cyclic voltammetry. The DNA binding properties of this Cr super(III) complex to CT DNA were demonstrated by absorption titration, melting t...

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Bibliographic Details
Published in:Bulletin of the Chemical Society of Japan 2005-01, Vol.78 (2), p.270-276
Main Authors: Vijayalakshmi, Rajamanickam, Kanthimathi, Mookandi, Parthasarathi, Ramakrishnan, Nair, Balachandran Unni
Format: Article
Language:English
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Summary:A new dichlorochromium(III) complex with the 2,3- dicyanodipyridoquinoxaline ligand has been synthesized and characterized by UV-visible, mass spectroscopy, and cyclic voltammetry. The DNA binding properties of this Cr super(III) complex to CT DNA were demonstrated by absorption titration, melting temperature and viscosity measurements. Hypochromism in the absorption spectra, an increase in the denaturation temperature and changes in the viscosity in the presence of the complex indicate that the complex binds to DNA through the intercalative mode. Based on the data obtained from molecular- mechanics calculations, an intercalative mode of binding to d(GC) sub(12) through a minor groove is favored. The title complex promotes the cleavage of plasmid pBR322 DNA in the presence of peroxide, and a slight retardation in the mobility of plasmid DNA.
ISSN:0009-2673
DOI:10.1246/bcsj.78.270