Association between HIV-1 subtype and drug resistance in Nigerian infants

Abstract Background Many lines of evidence point to HIV-1 subtype-specific differences in the development of drug resistance mutations. While variation between subtype C and others has been extensively explored, there has been less emphasis on subtypes common to West Africa. We examined a previously...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2019-01, Vol.74 (1), p.172-176
Main Authors: Chaplin, Beth, Akanmu, Alani Sulaimon, Inzaule, Seth C, Samuels, Jay Osi, Okonkwo, Prosper, Ilesanmi, Oluwafunke, Adewole, Isaac F A, Asadu, Chukwuemeka, Khamofu, Hadiza, Mpazanje, Rex, Ndembi, Nicaise, Odafe, Solomon, Sigaloff, Kim C E, Ngige, Evelyn Nkadi, Abatta, Emmanuel Okechukwu, Akinbiyi, Gbenga, Dakum, Patrick, Rinke de Wit, Tobias F, Kanki, Phyllis
Format: Article
Language:English
Subjects:
Drug Resistance, Viral
Female
Genotype
HIV Infections - virology
HIV-1 - drug effects
HIV-1 - genetics
Humans
Infant
Infant, Newborn
Male
Mutation Rate
Mutation, Missense
Nigeria
pol Gene Products, Human Immunodeficiency Virus - genetics
Sequence Analysis, DNA
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Summary:Abstract Background Many lines of evidence point to HIV-1 subtype-specific differences in the development of drug resistance mutations. While variation between subtype C and others has been extensively explored, there has been less emphasis on subtypes common to West Africa. We examined a previously described national survey of pretreatment drug resistance in HIV-1-infected Nigerian children aged
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dky380