Brain imaging can predict neurodevelopmental outcome of Group B streptococcal meningitis in neonates

Aim The association between cranial ultrasound (CUS) or magnetic resonance imaging (MRI) lesions and neonatal Group B streptococcal (GBS) meningitis outcome has not been studied in detail. Methods This retrospective study assessed CUS, cranial MRI and neurodevelopmental outcome in 50 neonates with G...

Full description

Saved in:
Bibliographic Details
Published in:Acta Paediatrica 2019-05, Vol.108 (5), p.855-864
Main Authors: Martis, J M S, Bok, L A, Halbertsma, F J J, Straaten, H L M, Vries, L S, Groenendaal, F
Format: Article
Language:English
Subjects:
Cognitive ability
Cranial ultrasound
Group B streptococcus
Infants
Intensive care units
Lesions
Magnetic resonance imaging
Meningitis
Neonates
Neurodevelopmental outcome
Neuroimaging
Newborn infant
NMR
Nuclear magnetic resonance
Skull
Streptococcus
Streptococcus infections
Substantia alba
Substantia grisea
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim The association between cranial ultrasound (CUS) or magnetic resonance imaging (MRI) lesions and neonatal Group B streptococcal (GBS) meningitis outcome has not been studied in detail. Methods This retrospective study assessed CUS, cranial MRI and neurodevelopmental outcome in 50 neonates with GBS meningitis admitted to three neonatal intensive care units in the Netherlands between 1992 and 2014. Death, cognitive outcome and motor outcome below −1 SD were considered as adverse outcomes. Results CUS was available in all and MRIs in 31 infants (62%) with 28 CUS (56%) and 27 MRIs (87%) being abnormal. MRI lesions were multifocal (n = 10, 37%), bilateral (n = 22; 82%) and extensive (n = 11; 41%). A total of 10 died in the neonatal period. Median age at assessment was 24 months. Among survivors, abnormal cognitive outcome and motor outcome were seen in 23 and 20 patients, respectively. Abnormal CUS [odds ratio (OR) 5.3, p = 0.017], extensive bilateral deep grey lesions (OR 6.7, p = 0.035) and white matter lesions (OR 14.0, p = 0.039) correlated with abnormal motor outcome. Extensive bilateral deep grey matter lesions correlated with abnormal cognitive outcome (OR 8.1, p = 0.029). Conclusion Abnormal CUS and the most severely affected MRIs were associated with poor neurodevelopmental outcome in neonatal GBS meningitis.
ISSN:0803-5253
1651-2227
DOI:10.1111/apa.14593