Intracranial infiltration by recurrent scalp dermatofibrosarcoma protuberans

Abstract Dermatofibrosarcoma protuberans (DFSP) of the scalp is a rare soft tissue sarcoma. A 22-year-old male with DFSP, who had undergone several surgical excisions and radiotherapy, presented with a mild left lower-limb paresis. An MRI scan demonstrated a huge mass extending throughout the fronto...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2009-10, Vol.16 (10), p.1358-1360
Main Authors: Abe, Tatsuya, Kamida, Tohru, Goda, Makoto, Inoue, Ryo, Fujiki, Minoru, Kobayashi, Hidenori, Hatano, Yutaka, Shibuya, Hiromi, Fujiwara, Sakuhei, Terashi, Hiroto, Mori, Teruaki
Format: Article
Language:English
Subjects:
Dermatofibrosarcoma
Dermatofibrosarcoma - pathology
Dermatofibrosarcoma - surgery
Humans
Intracranial recurrence
Invasion
Magnetic Resonance Imaging
Male
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Neurology
Radiosurgery - methods
Scalp
Scalp - pathology
Scalp - surgery
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Virchow-Robin space
Young Adult
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Summary:Abstract Dermatofibrosarcoma protuberans (DFSP) of the scalp is a rare soft tissue sarcoma. A 22-year-old male with DFSP, who had undergone several surgical excisions and radiotherapy, presented with a mild left lower-limb paresis. An MRI scan demonstrated a huge mass extending throughout the frontoparietal convexity. A macroscopically complete removal of the mass was performed. Despite this, there were several recurrences; thereafter, the patient underwent surgery, stereotactic radiosurgery and chemotherapy. The histological findings demonstrated a DFSP that both abutted and occasionally invaded the adjacent brain cortex, while extending along the Virchow-Robin spaces. Due to the highly infiltrating characteristics of DFSP, another approach, such as the use of molecular-targeted agents, will be required to significantly improve the clinical outcome.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2008.07.088