The expression of Indoleamine 2, 3-dioxygenase (IDO) is reduced in granulomas from BCG vaccinated cattle compared to granulomas from unvaccinated controls after experimental challenge with Mycobacterium bovis

Bovine tuberculosis (bTB), mainly caused by Mycobacterium bovis (M. bovis), is a major economic disease of livestock worldwide. Vaccination is considered as a potentially sustainable adjunct to the current control strategy. Cattle vaccination with the live attenuated M. bovis bacillus Calmette-Gueri...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary immunology and immunopathology 2018-09, Vol.203, p.52-56
Main Authors: Garcia-Jimenez, Waldo L., Villarreal-Ramos, Bernardo, Grainger, Duncan, Hewisnon, R. Glyn, Vordermeier, Hans M., Salguero, Francisco J.
Format: Article
Language:English
Subjects:
Animals
BCG Vaccine - immunology
BCG Vaccine - pharmacology
Bovine tuberculosis
Cattle
Granuloma - enzymology
Granuloma - immunology
Granuloma - metabolism
Granuloma - veterinary
IDO
Immunohistochemistry
Indoleamine 2,3-dioxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism
Lymph Nodes - enzymology
Lymph Nodes - metabolism
Mycobacterium bovis
Mycobacterium bovis - immunology
Tuberculosis, Bovine - enzymology
Tuberculosis, Bovine - immunology
Tuberculosis, Bovine - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bovine tuberculosis (bTB), mainly caused by Mycobacterium bovis (M. bovis), is a major economic disease of livestock worldwide. Vaccination is considered as a potentially sustainable adjunct to the current control strategy. Cattle vaccination with the live attenuated M. bovis bacillus Calmette-Guerin (BCG) confers variable protection; the reasons for this variability are not understood. Indoleamine 2, 3-dioxygenase (IDO), through the catalysis of tryptophan, is thought to have an immunoregulatory role in the immune response to Mycobacterium tuberculosis (M. tuberculosis). In this work, we used immunohistochemistry and digital image analysis to evaluate the presence of IDO in granulomas at different stages of development in cattle that had been BCG-vaccinated or not and then challenged with M. bovis. Our results show that the expression of IDO in granulomas from non-vaccinated M. bovis challenged animals is higher than in granulomas from BCG-vaccinated M. bovis challenged animals. Thus, it is possible that vaccination with BCG prevents the induction of what are thought to be host immunosuppressive pathways by M. bovis, which contribute to pathology during the disease.
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2018.08.002