Errors in power-law estimations of inflow rates for intracranial aneurysm CFD

Patient-specific inflow rates are rarely available for computational fluid dynamics (CFD) studies of intracranial aneurysms. Instead, inflow rates are often estimated from parent artery diameters via power laws, i.e. Q ∝ Dn, reflecting adaptation of conduit arteries to demanded flow. The present stu...

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Bibliographic Details
Published in:Journal of biomechanics 2018-10, Vol.80, p.159-165
Main Authors: Chnafa, C., Bouillot, P., Brina, O., Najafi, M., Delattre, B.M.A., Vargas, M.I., Pereira, V.M., Steinman, D.A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aneurysm
Aneurysms
Angiography
Arteries
Carotid artery
Carotid Artery, Internal - diagnostic imaging
Carotid Artery, Internal - physiology
Computational fluid dynamics
Computer applications
Female
Flow rates
Flow velocity
Humans
Hydrodynamics
Image processing
Image segmentation
Inflow
Intracranial Aneurysm - diagnostic imaging
Intracranial Aneurysm - physiopathology
Magnetic Resonance Imaging
Male
Middle Aged
Models, Cardiovascular
Normalizing
Patients
Phase contrast
Power law
Stress, Mechanical
Studies
Variation
Veins & arteries
Velocity
Wall shear stress
Wall shear stresses
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Summary:Patient-specific inflow rates are rarely available for computational fluid dynamics (CFD) studies of intracranial aneurysms. Instead, inflow rates are often estimated from parent artery diameters via power laws, i.e. Q ∝ Dn, reflecting adaptation of conduit arteries to demanded flow. The present study aimed to validate the accuracy of these power laws. Internal carotid artery (ICA) flow rates were measured from 25 ICA aneurysm patients via 2D phase contrast MRI. ICA diameters, derived from 3D segmentation of rotational angiograms, were used to estimate inflow rates via power laws from the aneurysm CFD literature assuming the same inlet wall shear stress (WSS) (n = 3), velocity (n = 2) or flow rate (n = 0) for all cases. To illustrate the potential impact of errors in flow rate estimates, pulsatile CFD was carried out for four cases having large errors for at least one power law. Flow rates estimated by n = 3 and n = 0 power laws had significant (p 
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2018.09.006