Plasma lipid profiling of tissue-specific insulin resistance in human obesity

Obesity-associated insulin resistance (IR) may develop in multiple organs, representing different aetiologies towards cardiometabolic diseases. This study aimed to identify distinct plasma lipid profiles in overweight/obese individuals who show muscle-IR and/or liver-IR. Baseline data of the Europea...

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Bibliographic Details
Published in:International Journal of Obesity 2019-05, Vol.43 (5), p.989-998
Main Authors: van der Kolk, Birgitta W, Vogelzangs, Nicole, Jocken, Johan W E, Valsesia, Armand, Hankemeier, Thomas, Astrup, Arne, Saris, Wim H M, Arts, Ilja C W, van Greevenbroek, Marleen M J, Blaak, Ellen E
Format: Article
Language:English
Subjects:
Adult
Biomarkers - metabolism
Blood lipids
Body mass
Body weight
Care and treatment
Chains
Chromatography
Chromatography, Liquid
Diglycerides
Female
Glucose
Glucose tolerance
Glucose Tolerance Test
Humans
Insulin
Insulin resistance
Insulin Resistance - physiology
Lipid Metabolism - physiology
Lipids
Lipids - blood
Liquid chromatography
Liver
Lysophosphatidylcholine
Male
Mass spectrometry
Mass spectroscopy
Medical research
Men
Middle Aged
Muscle, Skeletal - metabolism
Muscles
Obesity
Obesity - metabolism
Obesity - physiopathology
Organs
Overweight
Phospholipids
Sensitivity
Sexually transmitted diseases
Signal Transduction
Spectroscopy
STD
Triglycerides
Type 2 diabetes
Women
Young Adult
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Description
Summary:Obesity-associated insulin resistance (IR) may develop in multiple organs, representing different aetiologies towards cardiometabolic diseases. This study aimed to identify distinct plasma lipid profiles in overweight/obese individuals who show muscle-IR and/or liver-IR. Baseline data of the European multicenter DiOGenes project were used (n = 640; 401 women, nondiabetic BMI: 27-45 kg/m ). Muscle insulin sensitivity index (MISI) and hepatic insulin resistance index (HIRI) were derived from a 5-point oral glucose tolerance test. The 140 plasma lipids were quantified by liquid chromatography-mass spectrometry. Linear mixed models were used to evaluate associations between MISI, HIRI and plasma lipids. MISI was comparable between sexes while HIRI and triacylglycerol (TAG) levels were lower in women than in men. MISI was associated with higher lysophosphatidylcholine (LPC) levels (standardized (std)β = 0.126; FDR-p = 0.032). Sex interactions were observed for associations between HIRI, TAG and diacylglycerol (DAG) lipid classes. In women, but not in men, HIRI was associated with higher levels of TAG (44 out of 55 species) and both DAG species (stdβ: 0.139-0.313; FDR-p 
ISSN:0307-0565
1476-5497
DOI:10.1038/s41366-018-0189-8