A Concise Synthesis of Potential COX Inhibitor BRL‐37959 and Analogs Involving Bismuth(III) Catalyzed Friedel−Crafts Acylation

We report the development of a concise method of synthesizing possible cyclooxygenase (COX) inhibitor BRL‐37959, which is believed to be a potent nonsteroidal anti‐inflammatory drug (NSAID). The four‐step synthesis greatly increased the efficiency of compound production from commercially available s...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry & biodiversity 2018-12, Vol.15 (12), p.e1800334-n/a
Main Authors: Ahmed, Shamsul Arefin, Hinz, Damon J., Jellen, Marcus J., Hossain, M. Mahmun
Format: Article
Language:English
Subjects:
Acylation
Benzofuran
Benzoylation
Bismuth
bismuth(III) trifluoromethanesulfonate
Chemical synthesis
Inflammation
Inhibitors
NSAID
Prostaglandin endoperoxide synthase
synthesis design
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report the development of a concise method of synthesizing possible cyclooxygenase (COX) inhibitor BRL‐37959, which is believed to be a potent nonsteroidal anti‐inflammatory drug (NSAID). The four‐step synthesis greatly increased the efficiency of compound production from commercially available salicylaldehydes. The synthesis involved an optimized, bismuth(III) trifluoromethanesulfonate catalyzed benzoylation of a benzofuran ring.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201800334