Acute and Subchronic Toxicity of Arsenite and Zinc to Tadpoles of Rhinella arenarum Both Alone and in Combination

The current study evaluated acute and subchronic toxicity of arsenite (As 3+ ) and zinc (Zn 2+ ) to stage 25 tadpoles of Rhinella arenarum in both single and joint laboratory exposures. LC50 values obtained for As 3+ were elevated and remained within the range of 46 to 50 mg/L of As 3+ between 4 and...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2009-01, Vol.72 (14), p.884-890
Main Authors: Brodeur, Julie Céline, Asorey, Cynthia Melina, Sztrum, Abelardo, Herkovits, Jorge
Format: Article
Language:English
Subjects:
Animals
Arsenic
Arsenites - administration & dosage
Arsenites - toxicity
Bufonidae
Drug Administration Schedule
Ecological effects
Elevated
Environmental Pollutants - administration & dosage
Environmental Pollutants - toxicity
Exposure
Larva - drug effects
Lethality
Longevity
Mathematical analysis
Physical growth
Toads
Toxicity
Toxicology
Zinc
Zinc - administration & dosage
Zinc - toxicity
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Summary:The current study evaluated acute and subchronic toxicity of arsenite (As 3+ ) and zinc (Zn 2+ ) to stage 25 tadpoles of Rhinella arenarum in both single and joint laboratory exposures. LC50 values obtained for As 3+ were elevated and remained within the range of 46 to 50 mg/L of As 3+ between 4 and 17 d of exposure. Growth of tadpoles was completely inhibited with 30 mg/L of As 3+ , demonstrating the presence of ecologically relevant sublethal effects at concentrations lower than those resulting in lethality. With respect to Zn 2+ , a 96-h LC50 value of 2.49 mg/L was calculated in soft water. Contrary to results obtained for As 3+ , LC50 values of Zn 2+ gradually decreased with increasing exposure duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In joint exposures to both metals, the type of interaction observed between As 3+ and Zn 2+ was concentration dependent. Lethal effects of As 3+ were mitigated, unaffected, or potentiated by 0.01, 0.1, and 1-2 mg/L of Zn 2+ , respectively. However, although 0.01 mg/L of Zn 2+ significantly reduced lethality of As 3+ -exposed tadpoles, the same concentration of Zn 2+ did not help to reverse the stunt growth of these animals. Further studies need to examine which are the lowest concentrations As 3+ required to reduce growth and whether Zn 2+ serves to antagonize growth effects in this range of concentrations.
ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287390902959524